遗传性乳腺癌卵巢癌91例临床分析

目的探讨遗传性乳腺癌卵巢癌(HBOC)患者所患卵巢癌的临床特点。方法对91例HBOC患者的发病年龄、两癌发病间隔、病理类型、分期、家族史和生存期等进行分析。观察患者2,5年生存率,分析影响预后的因素。结果91例HBOC患者的中位生存期为47个月,2,5年生存率分别为71．2％和33．5％。卵巢癌的中位发病年龄为52岁,55岁前发病者占60．4％。在39例双原发癌中．两癌发病间隔≥60个月的患者20例,占51．3％。在91例卵巢癌中,浆液性腺癌最常见,有54例(59．3％)：Ⅲ、Ⅳ期患者70例(76．9％);低分化者54例(59．3％)。结论HBOC患者的卵巢癌发病年龄比散发者早,多数为晚期低分化,病理类型以浆液性腺癌为主,肿瘤分期和分化程度是影响患者预后的因素。对于乳腺卵巢双原发癌患者,卵巢癌的临床特点是影响其预后的主要因素。HBOC患者患卵巢癌后的中位生存期与散发性卵巢癌相似。

Clinical analysis of 91 cases of hereditary breast and ovarian cancer

OBJECTIVE: To explore the clinical characteristics of ovarian cancer in hereditary breast/ovarian cancer. METHODS: Ninety-one cases of hereditary breast/ovarian cancer were analyzed in terms of age, histological features, stage, familial history, survival time and prognostic factors by SPSS statistical software. RESULTS: The overall median survival time of the patients was 47 months, and the 2-and 5-year survival rates were 71.2% and 33.5%, respectively. The median age at diagnosis of ovarian cancer was 52 years with the majority of patients (60.4%) diagnosed before 55. Among 39 cases with double primary cancers, there are 20 cases (51.3%) with interval no less than 60 months. The most frequent histological types of ovarian cancer is serous adeno-carcinoma (59.3%). Most patients were in stage III or IV (76.9%) with poor differentiation (59.3%). CONCLUSION: The age of diagnosis in ovarian cancer in patients with hereditary breast/ovarian cancer is earlier than that of sporadic ones. Most of the cases were advanced with poor differentiation. Stage and differentiation are the prognostic factors. In patients with double primary cancers, the clinical pathological characteristics of ovarian cancer had the main effect on their prognosis. The survival of hereditary ovarian cancer is similar to that of sporadic ones.