In vitro interactions between piperaquine, dihydroartemisinin, and other conventional and novel antimalarial drugs |
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| Authors: | Davis Timothy M E Hamzah Juliana Ilett Kenneth F Karunajeewa Harin A Reeder John C Batty Kevin T Hackett Sara Barrett P Hugh R |
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| Affiliation: | University of Western Australia, School of Medicine and Pharmacology, Crawley, Western Australia 6959, Australia. tdavis@cyllene.uwa.edu.au |
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| Abstract: | In an in vitro assessment of antimalarial combinations, dihydroartemisinin (DHA) showed no interaction or was mildly antagonistic when combined with piperaquine, pyronaridine, or naphthoquine. Interactions between 4-aminoquinolines and related drugs were also indifferent/antagonistic. The clinical significance of mildly antagonistic DHA combinations is uncertain but may become important if parasite drug sensitivity declines. |
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