美托洛尔联合福辛普利对急性ST段抬高型心肌梗死患者心功能的影响

目的研究分析美托洛尔联合福辛普利对急性ST段抬高型心肌梗死患者心功能的影响。方法选取2015年1月—2016年8月本院收治的122例急性ST段抬高型心肌梗死患者作为研究对象,将所有患者按照随机数字表法分为2组各61例。对照组患者给予常规治疗,观察组在对照组治疗的基础上采用美托洛尔联合福辛普利治疗,对比两组临床疗效、治疗前后心功能指标变化、主要心脏不良事件发生率。结果对照组患者临床有效率为67.21%,低于观察组95.08%,差异有统计学意义(P0.05);治疗后,对照组患者左心室舒张末期内径及左心室收缩末期内径均大于观察组,左心室射血分数小于观察组,差异有统计学意义(P0.05);2组患者心力衰竭、心律失常、非致命性再梗死、梗死后心绞痛发生率比较,差异无统计学意义(P0.05)。结论对于急性ST段抬高型心肌梗死患者,采用美托洛尔联合福辛普利治疗可较好的恢复患者心功能水平,具有较高的安全性,。

Effect of metoprolol combined with fosinopril on cardiac function in patients with acute ST-elevation myocardial infarction

Objective To study the effect of metoprolol combined with fosinopril on cardiac function in patients with acute ST-elevation myocardial infarction.Methods A total of 122 patients with acute ST-elevation myocardial infarction were enrolled in our hospital from January 2015 to August 2016.All patients were divided into two groups according to the random number table method,with 61 cases in each group.The patients in the control group were given conventional therapy,and the patients in the observation group were treated with metoprolol combined with fosinopril on the basis of the control group.The clinical efficacy,cardiac function changes before and after treatment,the incidence of major adverse cardiac events were compared and analyzed.Results The clinical effective rate was 67.21％ in the control group,which was significantly lower than 95.08％ in the observation group,the difference was statistically significant (P ＜ 0.05);After treatment,the left ventricular end diastolic diameter and left ventricular systolic diameter were significantly higher in the control group than in the observation group.The left ventricular ejection fraction was less than that of the observation group (P ＜ 0.05);There was no significant difference in the incidence of heart failure,arrhythmia,non-fatal re-infarction and post-infarction angina pectoris between the two groups (P ＞0.05).Conclusion For patients with acute ST-segment elevation myocardial infarction,the use of metoprolol combined with fosinopril treatment can better restore the level of cardiac function in patients with high safety.