血清趋化因子配体5预测膀胱癌外科治疗后复发的价值

目的探讨血清趋化因子配体5(CXCL5)对膀胱癌外科治疗后复发的预测价值。方法选取行膀胱癌根治术的98例患者,根据病理分期分为肌层浸润性膀胱癌(MIBC)组和非肌层浸润性膀胱癌(NMIBC)组,比较2组的血清CXCL5水平和复发率,并分析所有患者术前血清CXCL5水平与其临床病理特征的关系。采用受试者工作曲线下面积(AUC)来评价其对膀胱癌复发的预测价值。结果 MIBC组的术前血清CXCL5水平均显著高于NMIBC组(P0.05)。年龄60岁、肿瘤位于膀胱底或膀胱体、M_1期、G_2~G_3级者的术前血清CXCL5水平显著升高(P0.05)。所有患者共随访6~36个月,复发36例(36.7%),MIBC组的复发率显著高于NMIBC组,复发者术前血清CXCL5水平显著高于无复发者(P0.05)。ROC曲线分析结果表明,术前血清CXCL5水平对MIBC、NMIBC的AUC为0.861(0.669~0.960,P0.05)、0.819(0.630~0.933,P0.05),其最佳临界值分别为828.9、589.3 pg/m L。结论术前血清CXCL5水平对膀胱癌患者术后复发有较好的预测价值。

Value of serum chemokine C-X-C motif ligand 5 in prediction of postoperative recurrence of surgery patients with bladder cancer

Objective To explore the value of serum chemokine C-X-C motif ligand 5 (CX-CL5) on postoperative recurrence of surgery patients with bladder cancer.Methods A total of 98 patients undergoing radical resection of bladder cancer in our hospital were divided into muscle invasive bladder cancer (MIBC) group and non muscle invasive bladder cancer (NMIBC) group according to pathological staging.Serum CXCL5 levels and its recurrence rate were compared between two groups,and the relationship between preoperative serum CXCL5 level and clinical pathological features was analyzed.The area under the receiver operating curve (AUC) was performed to predict value of recurrence of bladder cancer.Results Serum CXCL5 levels in MIBC group was significantly higher than that in NMIBC group (P ＜ 0.05),and the preoperative serum CXCL5 levels of patients aged 60 years or older,locating in the base or body of bladder,M1 stage,G2 ～ G3 were significantly higher.In this study,all patients were followed up for 6 ～ 36 months,and 36 cases (36.7％) recurred.The incidence of recurrence in MIBC group was significantly higher than that in NMIBC group (P ＜ 0.05).Preoperative serum CXCL5 levels of recurrent patients were significantly higher than that in patients without recurrence (P ＜ 0.05).ROC curve analysis showed that AUC of preoperative serum CXCL5 levels for recurrence of MIBC and NMIBC were 0.861 (0.669 ～0.960,P ＜0.05) and 0.819 (0.630 ～ 0.933,P ＜0.05),and the optimal critical values were 828.9 and 589.3 pg/mL,respectively.Conclusion Preoperative serum CXCL5 level is of great value in prediction of postoperative recurrence.