| 血卟啉衍生物激光治疗动物移植瘤的实验研究 |
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| 引用本文： | 赵素萍,陶正德,肖健云,彭勇炎,曾庆善,杨元华,刘政威.血卟啉衍生物激光治疗动物移植瘤的实验研究[J].中南大学学报(医学版),1987(2). |
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| 作者姓名： | 赵素萍 陶正德 肖健云 彭勇炎 曾庆善 杨元华 刘政威 |
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| 作者单位： | 湖南医学院第一附属医院耳鼻喉科教研室
(赵素萍，陶正德，肖健云，彭勇炎)，湖南医学院电镜室
(曾庆善)，湖南医学院病理解剖教研室
(杨元华)，湘潭大学物理系光学教研室(刘政威) |
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| 摘 要： | 本文报告了用国产 HpD 加氦—氖激光治疗小鼠艾氏腹水癌的实验结果。HpD 加激光、单纯激光、单纯 HpD 治疗后4周的肿瘤抑制率分别为70%、2%、-5%。通过对治疗前后~3H—TdR 掺入法淋转试验等证明,该疗法对小鼠的免疫功能无抑制作用。HpD 激光治疗后电镜动态观察表明,最早出现损害的是线粒体和粗面内质网。
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| 关 键 词： | 血卟啉衍生物 淋巴细胞转化 肿瘤移植 动物 小鼠 超微结构 |
HEMATOPORPHYRIN DERIVATIVE-LASAR TREATMENT OF THE TRANSPLANTED TUMOR OF ANIMAL |
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| Zhao Suping,Tao Zhengde,Xiao Jiangyun,Peng Yongyuan,Zeng Qingshan,Yang Yuanhua,Liu Zhengwei.HEMATOPORPHYRIN DERIVATIVE-LASAR TREATMENT OF THE TRANSPLANTED TUMOR OF ANIMAL[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),1987(2). |
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| Authors: | Zhao Suping Tao Zhengde Xiao Jiangyun Peng Yongyuan Zeng Qingshan Yang Yuanhua Liu Zhengwei |
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| Institution: | Zhao Suping~1,Tao Zhengde~1,Xiao Jiangyun~1,Peng Yongyuan~1,Zeng Qingshan~2,Yang Yuanhua~3,Liu Zhengwei~4 1.Department of Otolaryngology,The First Affiliated Hospital,Hunan Medical College,2.Laboratory of Electron Microscope,Hunan Medical College,3.Department of Pathological Anatomy,Hunan Medical College,4.Department of Optic,Hiang Tan University. |
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| Abstract: | The hemotoporphyrin-derivative(HpD)-lasar therapy was studied on thetreatment of transplanted ascites cancer of mice.The preliminary result showedthat the tumor inhibition index was significantly higher(P<0.01-0.05)inexperimental group(70%)than in control groups(2%,-5%).There was nodetectable immunosuppressive effect as evidenced by the ~3H-TdR incorporatedlymphocytoblast transformation assay performed both before and after the treat-ment.The longitudinal studies of the photoradiated tumor tissues taken atdifferent time intervals after the treatment highly suggested that the mitochon-dria and rough endoplasmic reticulum were among the first organelles to havebeen damaged. |
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| Keywords: | Hematoporphyrins Lymphocyte transformation Neoplasm transplantion Mice Animal Ultrasturcture |
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