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| 人表皮生长因子受体家族在肺癌中的表达研究 | |
| 引用本文： | 邓在春,葛棣,张敦华,谭云山,白春学,徐永华. 人表皮生长因子受体家族在肺癌中的表达研究[J]. 中华结核和呼吸杂志, 2002, 25(4): 207-209,I001 |
| 作者姓名： | 邓在春 葛棣 张敦华 谭云山 白春学 徐永华 |
| 作者单位： | 1. 宁波大学附属医院呼吸科,315020 2. 200032,上海,复旦大学附属中山医院胸外科 3. 200032,上海,复旦大学附属中山医院肺科 4. 200032,上海,复旦大学附属中山医院病理科 5. 中国科学院上海细胞生物研究所 |
| 摘 要： | 目的：检测人表皮生长因子受体（HER）及其基因（erbB)家族在非癌肺组织和肺癌组织中的表达，探讨HER过度表达与肺癌临床病理的关系。方法：采用免疫组化的方法分别检测20例非癌肺组织及有随访资料的70例肺癌（43例鳞癌和27例腺癌）组织中HER的表达。结果：HER在非癌肺组织存在阳性表达（＋），肺癌中存在HER1，HER2，HER4的过度表达，该过度表达与肺癌病理类型，分化程度不相关，而与肺癌淋巴结转移，TNM分期，患者术后生存率相关，结论：erbB1,erbB2,erbB4是晚期肺癌生长的调控基因，干预期过度表达可能是治疗晚期肺癌的有效方法。 |
| 关 键 词： | 肺癌 人表皮生长因子受体 家族 基因表达 |
The expression of erbB/HER family in lung cancer |
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| DENG Zaichun,GE Di,ZHANG Dunhua,TAN Yunshan,BAI Chunxue,XU Yonghua. The expression of erbB/HER family in lung cancer[J]. Chinese journal of tuberculosis and respiratory diseases, 2002, 25(4): 207-209,I001 | |
| Authors: | DENG Zaichun GE Di ZHANG Dunhua TAN Yunshan BAI Chunxue XU Yonghua |
| Affiliation: | Department of Pulmonary Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China. |
| Abstract: | Objective To study the expression of human epidermal growth factor receptor (HER) family in lung cancer. Methods Paraffin-embedded tissues from 70 cases of lung cancer (43 cases of squamous cell cancer and 27 cases of adenocarcinoma) and 20 cases of non-cancerous lung diseases were stained for the expression of HERs by means of immunohistochemistry.Results All HERs were weakly expressed in non-cancerous lung tissues; over-expression of HER_1,HER_2,HER_4,HER_ 1+2 ,HER_ 1+4 and HER_ 2+4 and HER_ 1+2+4 was found in lung cancer and correlated with lymph node metastasis,TNM staging and post-operation survival.Conclusions erbB_1,erbB_2 and erbB_4 are the genes regulating the growth of lung cancer at advanced stages.Targeting the HER_1,HER_2 and HER_4 over-expression might be a new approach to the treatment of lung cancer at advanced stages. |
| Keywords: | erbB gene HER protein Lung neoplasms |
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