美国与中国两组结直肠克罗恩病患者临床表现及病情严重程度比较

Objective To evaluate the differences in clinicopathological characteristics and severity between American and Chinese patients with colorectal Crohn disease (CD). Methods Between March 1985 and September 2004, 68 patients with colorectal CD in Cleveland Clinic Florida (America)and 85 patients with colorectal CD in the 301 Hospital (China) were enrolled in the study. Data of two groups,including demographics, clinical characteristics, extraintestinal manifestations, presenting symptoms, location and pathological characteristics,were compared. Results 60.3% of American patients and 36.5% of Chinese patients were female (P=0.003). 11.8% of American patients and 1.2% of Chinese patients had a family history of CD(P=0.016). American patients had a significantly higher rate of extraintestinal disease (39.7% vs 20.0%), abscess(19.0% vs 0), and anorectal fistulas(51.5% vs 0). American patients had significantly more extensive disease than Chinese patients (pancolitis:44.1% vs 4.7% ,P＜0.01). American patients had a significantly higher rate of disease involving the ascending colon, transverse colon, descending colon, sigmoid colon, anorectal area compared with Chinese patients (all P＜0.05). Conclusions American patients with colorectal Crohn disease seem to have a female predominance, a higher rate of CD family history, to involve the distal intestinal tract more often,and have more severe clinical manifestation and pathological process, as compared with Chinese patients.

Comparison of clinical manifestation and severity between hospital-based American and Chinese patients with colorectal Crohn disease