地鼠颊囊癌生成过程中红细胞免疫功能的动态检测

将40只金黄地鼠随机分为4组，每组10只，1组用于空白对照，其余3组用0．5％二甲基苯并蒽丙酮溶液涂布颊囊粘膜，每周3次诱癌，至第6、9、12周时颊粘膜依次表现为白斑、原位癌和浸润癌。在诱癌全过程中动态检测红细胞免疫功能和血浆纤维蛋白原含量。结果发现，癌变前两者均无变化，肿瘤生成后红细胞免疫功能下降、纤维蛋白原含量升高，此变化随肿瘤的继续生长而加剧。本文还对上述变化的原因进行了初步分析。

A follow up determinion on the RBC immune function during the DMBA induce hamster cheek pouch carcinoma.

Divided 40 golden hamsters into four groups, each group has 10 hamsters. One group iscontrol group, the other three group hamsters were painted by 0. 5% DMBA in acetone on cheek pouchthree times a week for 6,9 and 12 weeks respectively. Histology showed that the cheek pouch dlsplaiedleukoplakia after 6 weeks treated by DMBA and preivasive carcinoma after 9 weeks and infiltrationcarcinoma after 12 weeks. In the all course of inducing buccal carcinoma, we determined the red bloodcell immune function and the content of fibrinogen. The result was shown, they were not change beforebuccal cancerization. When the buccal carcinoma was appeared, the RBC immune function reduced andthe content of fibrinogen increased. These changes intensified along with cancer growth. We alsoanalysed the reason of those changes.