步长脑心通胶囊对颈动脉粥样硬化软斑块的临床研究

目的观察脑心通胶囊对颈动脉粥样硬化斑块中软斑块的干预作用。方法符合入选标准的100例患者随机分为对照组和治疗组，每组50例，对照组为常规治疗；治疗组在常规治疗的基础上加用脑心通胶囊4粒（1.2g）,3次/d，疗程均为6个月。每3个月，用彩色多普勒超声检测两组患者颈动脉和椎动脉，记录斑块性质，大小和数目，并检查血糖和血脂，同时记录不良反应情况。结果①两组经治疗后在软斑块消退、软斑块转为硬斑块，软斑块数目体积减少，无变化和恶化等方面比较，差异有显著性（P〈0.01）；②两组治疗6个月-1年脑血管病事件发生比较，治疗组较对照组降低，差异有显著性（P〈0.01）。结论脑心通胶囊能有效地干预颈动脉粥样硬化斑块中软斑块的发生发展并降低及脑血管疾病事件发生。

Clinical Study of the Effect of Troxerutin and Diprophylline Capsules on Soft Plaque in Carotid Atherosclerosis

Objective To observe the effect of troxerutin and diprophylline capsules on soft-plaque in carotid atherosclerosis. Methods One hundred were divided into two groups randomly. The conventional therapy was adopted in the control group and the conventional therapy combined with troxerutin and diprophylline capsules（take orally, 1.2g, tid, for 6 months） in the treating group. The carotid and vertebral artery were examined by Colour-code Doppler ultrasonography every 3 months. The nature, size and number of plaque as well as the adverse reaction of the drug were recorded. The level of blood glucose and blood lipid was detected. Results （1）Therc was no significant difference between the two groups as regards to the sex, age and number of plaque （ P 〉 0.05 ） ; （2）There was significant difference as regards to the plaque regression, soft-plaque changing into the hard-plaque and the deterioration of soft-plaque （P 〈 0. 01 ） ;（3）The incidence rates of the cardio-cerebrovascular disease in the treating group was lower than that in control group and the difference has statistical significance（P 〈 0.01 ）. Conclusion Troxerutin and diprophylline capsules may influence the development of carotid atherosclerotic soft-plaque, and lower the incidence rate of the cerebrovascular disease.