紫外分光光度法测定华法林钾片的溶出度

目的:建立测定华法林钾片溶出度的方法。方法:采用紫外分光光度法,以0.1mol·L-1盐酸为溶媒,溶媒体积900mL,转速50r·min-1,30min取样,在283nm波长处测定其溶出度。结果:华法林钾检测浓度的线性范围为5～30μg·mL-1(r=0.9999);平均回收率为100.53%(RSD=0.69%);3批样品30min溶出度均在90%以上。结论:本方法简便、准确,结果可靠,可用于该制剂的溶出度测定。

Determination of Dissolution of Warfarin Potassium Tablets by UV Spectrophotometry

OBJECTIVE： To establish a method for the determination of dissolution of warfarin potassium tablets. METHODS： The dissolution of warfarin potassium tablets was determined by UV spectrophotometry at a detection wavelength of 283 nm with 0.1 mol · L^- 1 hydrochloric acid as the solvent at a volume of 900 mL. The rotation speed was 50 r · min ^-1 and the sampling time was 30 min. RESULTS： The method showed a good linear relationship in the range of 5-30μg · mL ^-1（ r = 0.999 9）. The average recovery was 100.53% （RSD = 0.69% ）. The dissolutions of 3 batches of samples were all above 90%. CONCLUSION： The method is simple, accurate and reliable, and it can be applied for the determination the dissolution of warfarin potassium tablets.