甘精胰岛素强化治疗新诊断2型糖尿病疗效观察

目的:观察睡前皮下注射甘精胰岛素与中效胰岛素(NPH)对新诊断2型糖尿病患者的疗效。方法:将64例新诊断2型糖尿病患者分为A、B组,分别睡前皮下注射甘精胰岛素和睡前皮下注射NPH,2组均在饮食控制及一定活动量基础上皮下注射短效胰岛素。比较2组治疗后平均空腹血糖、血糖达标时间、日内血糖漂移、低血糖发生率及胰岛素总用量。结果:甘精胰岛素组在治疗后平均空腹血糖、血糖达标时间、日内血糖漂移、低血糖发生率等方面均低于NPH组(P<0.05)。结论:甘精胰岛素联合短效胰岛素治疗新诊断2型糖尿病疗效好,安全性高。

Insulin Giargine Intensification Therapy for Initial Type 2 Diabetes Mellitus

OBJECTIVE： To observe the clinical efficacy of insulin glargine versus intermediate-acting insulins （NPH） injected subcutancously at bedtime in initial diabetes mellitus cases. METHODS： 64 initial type 2 diabetes mellitus cases were assigned to insulin glargine group （A） or NPH insulin group （B）. Both groups were subcutancously injected with short - action insulin on the basis of alimentary control and a certain amount of activity. Comparison was made between the two in respect of fasting blood glucose （FBG）, duration of glycemic control, glycemic excursion, hypoglycemic incidence and total daily insulin dose. RESULTS： FBG, duration of glycemic controlling, glycemic excursion and hypoglycemic incidenc were lower in glargine insulin group than in NPH group （P 〈 0.05） . CONCLUSION： Insulin glargine combined short- action insulin is of good efficacy and high safety for initial type 2 diabetes mellitus cases.