肝细胞生长因子对膝关节软骨影响的临床意义

目的 研究前列腺素Ｅ２（ＰＧＥ２）参与关节软骨退变的进程机理，以及肝细胞生长因子（ＨＧＦ）对膝关节软骨损伤修复的作用机理。方法 对符合临床诊断标准的３０个膝关节，分别给予膝关节腔注射肝细胞生长因子，每天１次，每次２ｍｌ，观察ＰＧＥ２、尿中１型胶原（ｃｒｏｓｓｌａｐｓ）、碱性磷酸酶（ＡＫＰ）以及临床症状的改善程度，并做了给药６周后与给药有的对比研究。结果 给药６周后ｃｒｏｓｓｌａｐｓ和ＰＧＥ２与给药

Clinical effect of hepatocyte growth factor on articular cartilage of the knee

Objective To explore the mechanism of prostaglandins E 2(PGE 2) affecting cartilage degeneration stage and the effect of hepatocyte growth factor(HGF) on the repair of injured articular cartilage of the knee. Methods HGF(2 ml,once daily)were injected into 30 knee joints which met to clinical diagnostic standard of osteoarthritis.The PGE 2,crosslaps,AKP and the improvement of clinical symptom were investigated.Results After 6 weeks,the contents of PGE 2 and crosslaps decreased notably compared with that of before the treatment (P<0 01,P<0 001),meanwhile the clinical symptoms were also improved to different extents.ConclusionPGE 2 had involvements in certain stages of articular cartilage damage.HGF had a promotion effect on the repair process of cartilage.