支气管哮喘患儿治疗前后血清GM-CSF、CGRP检测的临床意义

目的:探讨了支气管哮喘患儿血清巨噬细胞集落刺激因子(GM-CSF)和降钙素基因相关肽(CGRP)水平的变化及意义.方法:应用放射免疫分析对33例支气管哮喘患儿进行了血清GM-CSF和CGRP测定,并与35名正常健康儿作比较.结果:支气管哮喘患儿在治疗前血清GM-CSF水平非常显著地高于正常儿组(P＜0.01),血清CGRP水平则显著地低于正常儿组(P＜0.01),经治疗3个月后则与正常儿组比较无显著性差异(P＞0.05).结论:血清GM-CSF水平的升高和CGRP水平的降低是支气管哮喘患儿发病的病理因素之一,有重要临床价值.

Clinical Significance of Determination of Changes of Serum GM-CSF,CGRP Levels After Treatment in Pediatric Patients with Bronchial Asthma

Objective To explore the changes of serum GM-CSF and CGRP levels both before and after treatment in pediatric patients with bronchial asthma. Methods Serum GM-CSF and CGRP levels were measured with RIA in 33 pediatric patients with bronchial asthma both before and after treatment as well as in 35 controls. Results Before treatment, the serum GM-CSF levels was significantly higher in the patients than those in the controls (P<0.01), but the serum CGRP level was significantly lower than those in controls (P<0.01). After three months treatment the levels were not significantly different from those in controls (P>0.05). Conclusion Abnormal high serum GM-CSF and low CGRP levels played important role in the pathogenesis of bronchial asthma in children.