首页 | 本学科首页   官方微博 | 高级检索  
     


Hemodynamic Effect of Propafenone and the Experience in Patients with Congestive Heart Failure
Authors:BONNIE J. BAKER,M.D.,&dagger  ,MICHAEL A. BRODSKY,M.D.,HA DINH,M.D.,&dagger  ,BYRON J. ALLEN,M.D.,BARBARA COTTER,L.P.N.,&dagger  ,CATHY LUCKETT,R.N., MARVIN L. MURPHY,M.D.,&dagger  
Affiliation:Division of Cardiology, University of California Medical Center at Irvine, Orange, CA.;The University of Arkansas for Medical Sciences, Little Rock, Arkansas
Abstract:
The effects of propafenone on left ventricular function and hemodynamics are presented in this study. In one group of 13 patients who underwent electrophysiological testing and subsequent chronic oral therapy with propafenone, eight had left ventricular ejection fractions determined by nuclear study before and during therapy with the drug. Initial measurements ranged from 22% to 39% (mean 30%), while those on chronic therapy showed no statistical difference and ranged from 22% to 48% (mean 30%). In a separate dose titration study of 14 patients, left ventricular ejection fraction showed a modest but significant decrease (52%± 9% to 48%± 11%; p < 0.05). This change was more marked in patients with an initial low ejection fraction. Propafenone appears to be safe in these patients but should be administered with caution in patients with particularly low ejection fractions.
Keywords:propafenone    left ventricular function    ejection fraction
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号