Evaluation of retinal nerve fiber layer thickness in children with autism spectrum disorders |
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| Affiliation: | 1. Ataturk University, Department of Child and Adolescent Psychiatry, Erzurum, Turkey;2. Ondokuz Mayis University, Department of Child and Adolescent Psychiatry, Samsun, Turkey;3. Giresun University, Department of Child and Adolescent Psychiatry, Giresun, Turkey;4. Çankırı State Hospital, Department of Ophthalmology, Turkey;5. Ondokuz Mayis University, Department of Ophthalmology, Samsun, Turkey;1. School of Psychological Science, University of Western Australia, Australia;2. Centre for the Advancement of Research on Emotion, School of Psychological Science, University of Western Australian, Australia;1. Boston University, Boston, MA 02215, USA;2. ImagiRation, Boston, MA 02135, USA;3. Independent researcher, Newton, MA 02459, USA;1. School of Education, University of California, Riverside, Riverside, CA 95251, USA;2. College of Liberal Arts, University of Massachusetts, Boston, Boston, MA 02125, USA;1. Department of Psychology, Goldsmiths, University of London, UK;2. Autism Research Centre, Department of Psychiatry, University of Cambridge, UK;1. CIUSSS Nord-de-l’Île-de-Montréal, 11 822, avenue du Bois-de-Boulogne, Montréal, QC H3M 2X7, Canada;2. Department of Sociology, Université de Montréal, 3150 Jean-Brillant, Montreal, QC, H3T 1N8, Canada;3. Department of Psychology, Université du Québec à Montréal, CP 8888, succursale centre-ville, Montréal, QC H3C 3P8, Canada;4. Department of Department of Psychiatry and Addictology, Université de Montréal, 2900, boul. Édouard-Montpetit, bureau S-750, Montréal, QC H3T 1J4, Canada;1. School of Educational Psychology and Counselling, Faculty of Education, Monash University, Clayton, Victoria, Australia;2. Deakin Biostatistics Unit, Deakin University, Faculty of Health, Geelong, Australia;3. BehaviourWorks Australia, Monash Sustainable Development Institute, Monash University, Melbourne, Australia |
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| Abstract: | ![]()
BackgroundThe study compared retinal nerve fiber layer (RNFL) thickness, macular thickness, and macular volume of children with autism spectrum disorder (ASD) to those of healthy control group and correlated the RNFL thickness with symptom severity in children with ASD.MethodForty children between the ages of 7 and 12 with normal intelligence levels and who were diagnosed with ASD as per DSM-5 were included in the ASD group. The control group consisted of healthy children, who were matched with subjects in the ASD group in terms of age and gender. The Autism Behavior Checklist (ABC) and Childhood Autism Rating Scale (CARS) were used to evaluate the severity of the disease in the cases diagnosed with ASD. The RNFL, macular thickness, and macular volume of all participants were measured optical coherence tomography (OCT).ResultsThe temporal, temporal superior, nasal superior, temporal inferior, and global RNFL thicknesses were significantly lower in the ASD group than in the control group. There was no correlation between the RNFL thickness and ASD symptom severity. The macular thickness and volume were not significantly different between the groups.ConclusionOur data suggest that lower RNFL thickness may relate to atypical brain development in the ASD, and this can be measured in the retina. |
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| Keywords: | Autism spectrum disorders Retinal nerve fiber layer thickness Optical coherence tomography |
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