The relationship between nasal and conjunctival cultures of antimicrobial-resistant isolates of methicillin-resistant Staphylococcus aureus |
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| Institution: | 1. Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan;2. Institute of Medical Microbiology, Jena University Hospital, Jena, Germany;3. Department of Ophthalmology, Baptist Eye Institute, Kyoto, Japan;4. Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan;1. Department of Ophthalmology, Baylor College of Medicine, Houston, TX, United States;2. University Institute for Regenerative Medicine and Oral Implantology (UIRMI), Vitoria, Spain;3. Biotechnology Institute (BTI), Vitoria, Spain;1. Ophthalmic Plastic Surgery Services, L V Prasad Eye Institute, Hyderabad, Telangana, India;2. Centre for Ocular Regeneration, Prof. Brien Holden Centre for Eye Research (BHERC), L V Prasad Eye Institute, Hyderabad, Telangana, India;3. The Cornea Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India;1. Miami Veterans Administration Medical Center, 1201 NW 16th St, Miami, FL, 33125, USA;2. Bascom Palmer Eye Institute, University of Miami, 900 NW 17th Street, Miami, FL, 33136, USA;3. New York University Grossman School of Medicine, New York, NY, 10016, USA;4. Department of Ophthalmology, University of Tennessee Health Sciences Center, Hamilton Eye Institute, 930 Madison Avenue, Memphis, TN, 38163, USA;5. Departments of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL, 33620, USA;6. The Moffitt Cancer Center, Tampa, FL, 33620, USA;7. Research Service, James A. Haley Veterans Hospital, Tampa, FL, 33612, USA;8. Departments of Anatomy and Neurobiology, and Pharmaceutical Sciences, University of Tennessee Health Sciences Center, 930 Madison Avenue, Memphis, TN, 38163, USA;9. Memphis VA Medical Center, 1030 Jefferson Avenue, Memphis, TN, 38104, USA |
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| Abstract: | PurposeNasal screening is performed to avoid the complications of postoperative surgical site infections (SSI), especially those due to antimicrobial-resistant species such as methicillin-resistant Staphylococcus aureus (MRSA). This study examined the relationship between bacterial isolates from the conjunctiva and the nasal cavity.MethodsAll patients were diagnosed with ocular surface infections, and the organisms in the conjunctiva and the nasal cavity were isolated. We investigated the relationship of the following antimicrobial-resistant bacteria between the conjunctiva and the nose: MRSA, methicillin-resistant CNS (MRCNS), levofloxacin-resistant (LVFX-R) Corynebacterium spp. Data were analyzed using Fisher’s exact test, and the odds ratio was examined.ResultsThis study included 188 eyes of 188 subjects (87 males and 101 females; mean age 58.5 years, range 11–97 years). MRSA (4 eyes), MRCNS (29 eyes), and LVFX-R Corynebacterium spp. (41 eyes) were identified from the conjunctiva, and MRSA (6 eyes), MRCNS (38 eyes), and LVFX-R Corynebacterium spp. (41 eyes) were identified from the nasal cavity. There was a significant relationship detected between the conjunctiva and the nose for MRSA, MRCNS, and LVFX-R Corynebacterium spp. MRSA displayed high sensitivity (0.750, 95% confidence interval CI]; 0.301 to 0.987) and specificity (0.984, 95% CI; 0.953 to 0.996) in nasal cavity cultures, and the odds ratio was 181.00 times (95% CI; 18.41 to 2320).ConclusionThis study showed a significant relationship between conjunctival and nasal cultures of MRSA, MRCNS, and LVFX-R Corynebacterium spp., suggesting that nasal cavity culture is a potentially useful screening method for detecting resistant bacteria, especially MRSA, in the conjunctiva. |
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| Keywords: | MRSA MRCNS Fluoroquinolone-resistant Resistant bacteria Nasal colonization |
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