Evaluation of ganglion cell complex and retinal nerve fiber layer in children with spina bifida using optical coherence tomography |
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| Institution: | 1. Ümraniye Training and Research Hospital Ophthalmology Department, Turkey;2. Kartal Lütfi K?rdar Training and Research Hospital Ophthalmology Department, Turkey;3. Moorfields Eye Hospital, United Kingdom;4. T.C. Istanbul Demiro?lu Bilim University Medical Faculty Ophthalmology Department, Turkey;5. T.C. Istanbul Demiro?lu Bilim University Medical Faculty Neurosurgery Department, Turkey;1. Department of Breast and Thyroid Surgery, Xinjiang Medical University Affiliated Tumor Hospital, Urumqi, China;2. College of Software, Xinjiang University, Xinjiang, Urumqi 830046, China;3. College of Information Science and Engineering, Xinjiang University, Urumqi 830046, China;4. Medical District of Xingfu Road, General Hospital of Xinjiang Military Command of the Chinese PLA, Urumqi 830000, China;5. The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China;6. School of Computer Science, Beijing University of Technology, Beijing 100081, China;1. Institute of Animal Biochemistry and Genetics, Centre of Biosciences, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava 84005, Slovakia;2. Center for Interdisciplinary Biosciences, Technology and Innovation Park, P.J. Safarik University in Kosice, Jesenná 5, Ko?ice 04154, Slovakia;3. SAFTRA Photonics s r o., Moldavská cesta 51, Ko?ice 04011, Slovakia;4. Department for Biomaterials Research, Polymer Institute of the Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava 84541, Slovakia;1. Faculty of Science and Technology, The Technological and Higher Education Institute of Hong Kong, Tsing Yi, New Territories, Hong Kong;2. School of Graduate Studies, Lingnan University, Tuen Mun, Hong Kong;3. Fifth Affiliated Hospital, Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China;1. Department of Gynecology and Obstetrics, Konya City Hospital, Konya, Turkey;2. Department of Ophthalmology, Mardin Training and Research Hospital, Mardin, Turkey;1. National Institute of Lasers and Optronics College, Pakistan Institute of Engineering and Applied Sciences, Nilore, Islamabad 45650, Pakistan;2. Directorate General National Repository, Islamabad, Pakistan;3. Federal Medical College, Hanna Road, G-8/4, Islamabad, Pakistan;4. PAEC General Hospital, H-11, Islamabad, Pakistan;5. Air University, PAF Complex Sector E-9, Islamabad Pakistan |
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| Abstract: | PurposeSpina bifida (SB) is a congenital disorder caused by the incomplete fusion of the embryonic neural tube during spinal cord development. In this study, we used Spectral Domain Optic Coherence Tomography (SD-OCT) for retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) analyses and compared the results of healthy children and SB patients in a similar age group.MethodsOur study was planned prospectively and conducted between June 2017 and July 2019. One hundred eyes of 50 participants, consisting of 28 SB patients and 22 healthy children were included. In all cases, RNFL and GCC measurements were undertaken using SD-OCT. The circumpapillary RNFL analysis was conducted by examining the circular area of 3.45 mm in diameter around the centre of the optic disc. GCC parameters were determined with MM7 protocols by taking 15 vertical sections from a 7-mm macular square centred in the fovea.ResultsThe mean GCC thickness of the participants was 91.120 ± 5.224 µm in the control group and 91.696 ± 7.410 µm in the SB group. The difference between the two groups was not statistically significant (p > 0.05). The mean RNFL thickness was 102.499 ± 11.250 µm in the control group and 99.549 ± 15.235 µm in the SB group. The mean RNFL thickness of the patients in the SB group was lower than that of the control group, but the difference was not statistically significant (p > 0.05).ConclusionsIn this study, the lack of a statistically significant difference in the RNFL and GCC values between the SB and control groups can be attributed to successful clinical management. |
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