Association of birth weight with risk of autism: A systematic review and meta-analysis |
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| Affiliation: | 1. School of Nursing & Sixth Hospital, Peking University, Beijing, China;2. Peking University Sixth Hospital (Institute of Mental Health), Beijing, China;3. Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Disorders (Peking University), Beijing, China;4. Department of Mental Health, Beijing Children’s Hospital, Capital Medical University, Beijing, China;5. National Center for Children’s Health, China;6. School of Nursing, Peking University, Beijing, China;7. Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder (2018RU006), Chinese Academy of Medical Sciences, Beijing, China;8. PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China;1. Vanderbilt University Medical Center, 1500 21st Avenue South, Nashville 37212, TN, USA;2. Stanford University, School of Medicine, 401 Quarry Road, Palo Alto, CA 94305-5719, USA;1. Child and Adolescent Unit, Federal Neuropsychiatric Hospital, Enugu, Nigeria;2. Childhood Neuropsychiatric Disorders Initiatives (CNDI), Goshen Estate, Enugu, Enugu State, Nigeria;3. Ike Foundation for Autism (IFA), Abuja, FCT, Nigeria;4. Department of Mental Health, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria;5. Child and Adolescent Centre, Federal Neuropsychiatric Hospital, Yaba, Lagos (Oshodi Annex), Nigeria;6. Paediatric Neurology Unit, Enugu State University Teaching Hospital, Parklane, Enugu State, Nigeria;7. University Center for Excellence in Developmental Disabilities (UCEDD), Division of Developmental Medicine, Boston Children Hospital, 300 Longwood Avenue, Boston, MA, USA;8. Department of Pediatrics and Department of Psychiatry, Harvard Medical School, Boston, MA, USA;9. Scientific Section on Psychiatry of Intellectual/Developmental Disorders, World Psychiatric Association (WPA), Geneva, Switzerland;1. Developmental Pediatric Unit, Child Health Department, Sultan Qaboos University Hospital, Oman;2. Genetic Department, Sultan Qaboos University Hospital, Oman;1. College of Public Health, University of South Florida, Tampa, FL, USA;2. Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA;3. Harrell Center for the Study of Family Violence, College of Public Health, University of South Florida, Tampa, FL, USA;1. Institute of Child and Adolescent Health, School of Public Health, Peking University Health Science Center, Beijing 100191, China;2. Center of Children Psychology and Behavior, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China;3. Beijing Academy of Education Sciences, Beijing 100045, China;1. Faculty of Psychology, Southwest University, Chongqing, China;2. Rehabilitation Center for Children with Autism Spectrum Disorders, Ninth People’s Hospital, Chongqing, China;3. Collaborative Innovation Center of Assessment for Basic Education Quality, Beijing Normal University, China;4. Key Laboratory of Cognition and Personality, Ministry of Education, China |
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| Abstract: | BackgroundLow birth weight (LBW) has been reported to be a risk environmental factor for autism. However, the effects of normal birth weight (NBW) and macrosomia on autism have not been fully explored. This meta-analysis was conducted to explore the association between different birth weight levels and autism.MethodA systematic search was conducted in PubMed, Embase, and Scopus prior to April 26, 2020.ResultsA total of 28 studies were recognized as eligible. A significantly increased risk of autism was observed in relation to LBW (OR = 1.63, 95 % CI = 1.48–1.81, P < 0.00001) and macrosomia (OR = 1.11, 95 % CI = 1.05–1.18, P = 0.0005). NBW was found to be associated with a reduced risk of autism (OR = 0.74, 95 % CI = 0.67−0.82, P < 0.00001).ConclusionsLBW and macrosomia may increase the risk of autism, whereas NBW may reduce the risk of autism. |
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| Keywords: | Birth weight Macrosomia Autism Meta-analysis |
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