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| 1,3-二氢-1,3-二酮-2-氢-异吲哚衍生物的合成研究 | |
| 引用本文： | 杨跃,向东,郭举,郑永胜,叶斌,杨金亮,成丽. 1,3-二氢-1,3-二酮-2-氢-异吲哚衍生物的合成研究[J]. 四川大学学报(医学版), 2008, 39(4): 645-647 |
| 作者姓名： | 杨跃 向东 郭举 郑永胜 叶斌 杨金亮 成丽 |
| 作者单位： | 四川大学华西药学院药物化学教研室,成都,610041;四川省第六人民医院;四川大学华西医院人类疾病生物治疗国家重点实验室肿瘤中心;四川大学华西药学院现代药学专业教学中心室 |
| 摘 要： | 目的设计并合成沙利度胺的衍生物。方法氨基酸苄酯氨解N-邻苯二甲酰基-L-谷氨酸酐,所得产物经氢化脱苄后再与氨气成铵盐即得1,3-二氢-1,3-二酮-2H-异吲哚衍生物。结果成功地合成了4个未见文献报道的沙利度胺衍生物。并进行了结构表征。结论利用本方法可以在温和的条件下获得较高产率的目标产物。 |
| 关 键 词： | 沙利度胺 合成 1 3-二氢-1 3-二酮-2-氢-异吲哚衍生物 血管生成 |
Synthesis of 1,3-Dihydro-1,3-dioxo-2H-isoindole Derivatives |
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| YANG Yue,XIANG Dong,GUO Ju,ZHENG Yong-sheng,YE Bin,YANG din-liang,CHENG Li. Synthesis of 1,3-Dihydro-1,3-dioxo-2H-isoindole Derivatives[J]. Journal of Sichuan University. Medical science edition, 2008, 39(4): 645-647 | |
| Authors: | YANG Yue XIANG Dong GUO Ju ZHENG Yong-sheng YE Bin YANG din-liang CHENG Li |
| Affiliation: | The Central Teaching Laboratory for Modern Pharmacy, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. |
| Abstract: | Objective To synthesize a series of derivatives of Thalidomide.Methods The N-Phthaloyl-L-glutamic anhydride was ammonolyzed with amino acid benzyl esters,followed by hydrogenization.The reaction between the hydogenized products and ammonia gas produced ammonium salt,1,3-dihydro-1,3-dioxo-2H-isoindole derivatives.Results Four new derivatives of Thalidomide were obtained and confirmed by spectral detection.Conclusion The derivatives of Thalidomide can be efficiently synthesized under mild conditions. |
| Keywords: | Thalidomide synthesis 1 3-dhydro-1 3-dioxo-2H-isoindole derivatives Angiogenesis |
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