| 黄芩苷对创伤性休克患者血清炎性因子和氧自由基代谢的影响 |
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| 引用本文： | 刘骏达,赖真,郑克伟. 黄芩苷对创伤性休克患者血清炎性因子和氧自由基代谢的影响[J]. 中国基层医药, 2014, 0(11): 1617-1618 |
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| 作者姓名： | 刘骏达 赖真 郑克伟 |
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| 作者单位： | 汕头市潮南民生医院急诊科,广东省汕头515144 |
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| 基金项目： | 广东省汕头市医疗重点科技计划项目（2012002） |
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| 摘 要： | 目的探讨黄芩苷对创伤性休克患者血清炎性因子和氧自由基代谢的影响.方法38例创伤性休克的患者入院后予黄芩苷200 mg静脉注射,测定用药前及用药后1h静脉血TNF-α、IL-6、IL-8、丙二醛（MDA）的含量以及超氧化物歧化酶（SOD）活力.结果治疗前后比较,患者血清TNF-α、IL-6、IL-8、MDA含量均明显下降（t=7.32、6.12、20.21、16.10,均P＜0.05）,而SOD活力明显增加（t=1.69,P＜0.01）.结论黄芩苷可抑制创伤性休克患者血清炎性因子生成和释放,减轻氧化应激损伤.
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| 关 键 词： | 黄芩 休克,创伤性 自由基 细胞因子类 |
Effect of baicalin on inflammatory factors and oxygen free radical metabolism in patients with traumatic shock |
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| Liu Junda,Lai Zhen,Zheng Kewei. Effect of baicalin on inflammatory factors and oxygen free radical metabolism in patients with traumatic shock[J]. Chinese Journal of Primary Medicine and Pharmacy, 2014, 0(11): 1617-1618 |
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| Authors: | Liu Junda Lai Zhen Zheng Kewei |
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| Affiliation: | .( Department of Emergency, Shantou Chaonan Minsheng Hospital, Shantou, Guangdong 515144, China) |
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| Abstract: | Objective To investigate the effect of baicalin on inflammatory factors and oxygen free radical metabolism in patients with traumatic shock.Methods 38 patients with traumatic shock were treated with baicalin 200mg intravenous injection when admitted to hospital.Before and 1 h after treatment,TNF-α,IL-6,IL-8,MDA and SOD were measured in blood.Results Compared with before treatment,TNF-,IL-6,IL-8,and MDA levels were decreased after treatment （t =7.32,6.12,20.21,16.10,all P ＜ 0.05）,while SOD activity was significantly increased （t =1.69,P ＜ 0.01）.Conclusion Baicalin could inhibit the production and release of inflammatory factors TNF-α,IL-6,IL-8 in patients with traumatic shock,reduce the damage of oxygen free radicals to the cells.Early treatment with baicalin had protective effect on patients with traumatic shock. |
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| Keywords: | Baicalin Shock, traumatic Oxygen free radical Cytokine |
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