老年患者医院下呼吸道感染铜绿假单胞菌耐药性分析

目的探讨老年患者医院下呼吸道感染铜绿假单胞菌（PAE）耐药特点，为临床合理选用抗菌药物和预防泛耐药菌的发生提供依据。方法回顾性分析和评价2010年5月至2012年6月347例老年患者医院下呼吸道感染PAE药物敏感试验结果。结果347例老年患者医院下呼吸道感染PAE对抗菌药物的耐药较严重，氨苄西林、头孢唑啉耐药率均为100．O％，氨苄西林／舒巴坦、妥布霉素、磺胺甲嗯唑／甲氧苄啶耐药率分别为95．1％、86．8％、83．6％。对亚胺培南耐药率已达19．6％，泛耐药菌的检出率为4．9％。结论老年患者医院下呼吸道感染PAE耐药性日趋严重，应根据药物敏感试验结果合理选择抗菌药物，防止泛耐药菌的产生与流行。

Antibiotic resistance analysis in hospitalized elderly patients with lower respiratory tract infection caused by Pseudomonas Aeruginosa

Objective To explore the characterization of antibiotic resistance in hospitalized elderly patients with lower respiratory tract infection caused by Pseudomonas Aeruginosa, and provide scientific basis for clinical ra- tional use of antimicrobial drugs and prevent the emergence of pan-drug resistant bacteria. Methods The drug sensi- tive tests of 347 hospitalized elderly patients with lower respiratory tract infection caused by Pseudomonas Aeruginosa in Shandong provincial hospital affinited to Shandong university from May 2010 to June 2012 were analyzed retrospec- tively. Results The antimicrobial resistance of the 347 cases was rather serious. The resistant rates of ampicillin and cefazolin were both 100.0%. Followed by ampicillin/sulbactam, tobramycin, sulfamethoxazole/trimethoprim, the re- sistant rates were 95.1% ,86.8% and 83.6% respectively. The resistant rate of imipenem has reached 19.6%, and the detection rate of pan-drug bacteria was 4.9%. Conclusion The antibiotic resistance in hospitalized elderly pa- tients with lower respiratory tract infection caused by Pseudomonas Aeruginosa has become more and more serious. In order to prevent the emergence and prevalence of pan-drug resistant bacteria, antibacterial agents should be chosen reasonably according to the results of drug sensitive tests.