两种补铁途径治疗血液透析患者肾性贫血的临床疗效比较

目的比较不同补铁途径治疗血液透析患者肾性贫血的疗效及安全性。方法选取68例维持性血液透析的慢性肾衰竭（CRF）患者，按数字表格法随机分为两组，每组34例。对照组采用口服补铁，观察组采用静脉补铁，观察比较两组临床疗效。结果观察组总有效率61．76％，明显高于对照组的32．35％（x。=4．781，P=0．029）；两组患者Hb、Het、铁蛋白、转铁蛋白饱和度治疗后均比治疗前明显改善（t=4．931、4．213、5．429、5．107、7．018、6．472、7．821、7．530，均P〈0．05），观察组较对照组改善显著（t=4．082、3．968、4．395、4．139，均P〈0．05）。结论采用静脉补铁能显著改善血液透析患者贫血状态，明显提高血清铁指标，改善红细胞生成，迅速补充铁储备，纠正肾性贫血。

Clinical efficacy and safety of two ways iron therapy in hemodialysis patients with renal anemia

Objective To analyze the clinical efficacy and safety of different ways iron therapy in hemodialy- sis patients with renal anemia. Methods 68 cases of chronic renal failure patients treated with hemodialysis were randomly divided into two groups according to the digital form, each group had 34 cases. The control group was treated with oral iron while the observation group took intravenous iron, the clinical efficacy of the two groups was observed. Results The total effective rate of the observation group was 61.76% significantly higher than that of the control group＇s 32.35 % （ X2 = 4.781, P = 0. 029 ） ; Two groups of patients＇ Hb, Hct, SF, TSAT were significantly improved after treatment than before（ t = 4. 931,4. 213,5. 429,5. 107,7. 018,6. 472,7. 821,7. 530, all P 〈 0.05 ）, these parameters of the observation group were significantly improved than that of the control group （ t = 4. 082,3. 968, 4. 395,4. 139, all P 〈 0. 05 ）. Conclusion Intravenous iron approach can significantly improve anemia state in patients with CRF hemodialysis, increased serum iron indicators significantly, improved erythropoiesis, and quickly replenish iron stores, correct anemia in patients with CRF.