| 多抗甲素对小鼠抗体生成的作用 |
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| 引用本文： | 王天然,谢秩勋. 多抗甲素对小鼠抗体生成的作用[J]. 中国药理学通报, 1988, 0(3) |
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| 作者姓名： | 王天然 谢秩勋 |
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| 作者单位： | 成都军区总医院临床实验科 成都(王天然)，成都军区总医院临床实验科 成都(谢秩勋) |
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| 摘 要： | 多抗甲素(2.5～40mg/kg,ip)连续给药呈剂量依赖方式提高小鼠血清溶血素水平,促进脾脏生成抗体,增加脾脏有核细胞数。多抗甲素对循环抗体水平动力学过程无显著影响,该药于抗原刺激前3d给药促进抗体生成作用强于刺激后2d给药。
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| 关 键 词： | 多抗甲素 免疫药理 小鼠 绵羊红细胞 溶血素 脾脏 动力学 |
EFFECTS OF POLYACTIN A ON THE HEMOLYSIN ANTIBODY PRODUCTION IN MICE |
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| Wang Tianran and Xie Zhixun. EFFECTS OF POLYACTIN A ON THE HEMOLYSIN ANTIBODY PRODUCTION IN MICE[J]. Chinese Pharmacological Bulletin, 1988, 0(3) |
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| Authors: | Wang Tianran and Xie Zhixun |
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| Abstract: | In this report, the immunopharmacological effects of Polyactin A ( PAA ) were presented. When the SRBC immunized mice were administered daily 2. 5~40mg/kg ( ip ) of PAA for 3 or 5 days, the serum level of hemolysin, the antibody production in spleen and the number of nucleated cells of spleen were enhanced significantly; and the efficacy-dose dependency was evident in these experiments。 In spite of these effects, PAA didn't affect the kinetics of circulating antibody level.In other experiments, it was found that the efficiency was more potent when PAA was given before or simultaneously with SRBC immunization than given after. |
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| Keywords: | Polyactin A Immunopharmacology Mice SRBC Hemolysin antibody Spleen Kinetics |
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