茜草饮片炒炭前后止血机制的比较

目的:探讨茜草及茜草炭止血作用机制。方法:比较茜草和茜草炭对小鼠凝血时间、出血时间、血小板计数、毛细血管通透性、肝素和华发林所致病理性出血模型以及大鼠凝血酶时间(TT)、凝血酶原时间(PT)、部分凝血活酶时间(APTT)的影响。结果:茜草和茜草炭均能抑制小鼠腹腔毛细血管通透性,均能明显缩短大鼠TT、PT、APTT,但茜草炭作用强于茜草。茜草大小剂量和茜草炭饮片大剂量能提高小鼠血小板计数,明显对抗肝素及华发林的出血作用,茜草作用强于茜草炭。结论:茜草主要通过提高血小板计数,对抗肝素及华发林的出血来发挥止血作用;茜草炭主要通过抑制毛细血管通透性,缩短TT、PT、APTT来发挥止血作用;茜草和茜草炭的止血作用机制不同。

Comparison of Hemostasis Mechanisms between Radix Rubiae and Charred Radix Rubiae

Objective: To explore the hemostasis mechanisms of Radix Rubiae and charred Radix Rubiae.Methods: The effects of Radix Rubiae and charred Radix Rubiae were compared in terms of the clotting time,bleeding time,blood platelets count and capillary permeability on mice,and the TT,PT and APTT on pathologicalbleeding models incurred by Heparin and Warfarin and rats.Results: Radix Rubiae and charred Radix Rubiaeall canrestrain the capillary permeability of abdominal cavity in mouse,and obviously shortenthe TT,PT and APTT of rat,but charred Radix Rubiae was more effective than Radix Rubiae.The large and small doses of Radix Rubiae and the large dose of charred Radix Rubiae can elevate the blood platelets count,and obviously antagonize Heparin and Warfarin,and Radix Rubiae was more effective than charred Radix Rubiae.Conclusion: Radix Rubiae has the hemostasis effect through elevating the blood platelets count and antagonizing Heparin and Warfarin,but charred Radix Rubiae through restraining the capillary permeability and shortening the TT,PT and APTT.They have different hemostasis mechanisms.