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良性前列腺增生患者并发膀胱过度活动症与膀胱出口梗阻的关系
引用本文:朱智能,兰东阳,王海鹏,朱朝辉,庞自力. 良性前列腺增生患者并发膀胱过度活动症与膀胱出口梗阻的关系[J]. 临床泌尿外科杂志, 2013, 0(2): 145-147
作者姓名:朱智能  兰东阳  王海鹏  朱朝辉  庞自力
作者单位:华中科技大学同济医学院附属协和医院泌尿外科,武汉430022
摘    要:
目的:研究分析BPH患者并发膀胱过度活动症(OAB)与膀胱出口梗阻(BOO)程度的相关性。方法:163例BPH患者,根据OAB症状评分(OABSS)将患者进行严重程度分级:0级无尿急等OAB症状;OABSS为1级≤5分;2级6-11分;3级≥12分。经腹超声测定前列腺三径和前列腺突入膀胱的距离(IPP),尿动力学检查测定最大尿流率(Q_max)、剩余尿,最大尿流率时的逼尿肌压力(P&_det@Q_max),并计算出AG值,进行方差分析和相关性分析检验。结果:按OAB症状严重程度分为四组:0级44例,1级35例,2级46例,3级38例。OAB症状程度轻重与患者年龄、前列腺体积、最大自由尿流率等无相关。IPSS评分随OAB症状加重而增高,0~3级分别为(8.4±4.2)、(12.7±3.8)、(15.6±3.6)、(18.5±4.1)分(F=49.931,P=0.000);前列腺中叶增生程度(IPP)呈现显著性升高趋势,0~3级分别为(0.4±0.3)、(0.8±0.5)、(1.1±0.7)、(1.3±0.6)cm(F=21.385,P=0.000);剩余尿量显著增多,0-3级分别为(50.6±36.1)、(64.5±29.0)、(68.3±30.8)、(72.71±39.2)ml(F=3.345,P=0.021);P_det@Q_max显著增高,0~3级分别为(48.3±7.5)、(53.6±27.9)、(58.7±29.1)、(70.4±26.8)cmH2O(1cmH2O=0.098kPa,F=3.722,P=0.012)。BOO(AG〉40)发生率分别为:0级36.4%(16/44)、1级54.3%(19/35)、2级58.7%(27/46)、3级73.7%(28/38),显示OAB症状与AG值呈正相关(r=0.263,P=0.001)。结论:BPH患者并发膀胱过度活动症与膀胱出口梗阻存在显著相关性。

关 键 词:良性前列腺增生  膀胱过度活动症  膀胱出口梗阻

Correlation between overactive bladder and bladder outlet obstruction in benign prostatic hyperplasia
ZHU Zhineng,LAN Dongyang,WANG Haipeng,ZHU Zhaohui,PANG Zili. Correlation between overactive bladder and bladder outlet obstruction in benign prostatic hyperplasia[J]. Journal of Clinical Urology, 2013, 0(2): 145-147
Authors:ZHU Zhineng  LAN Dongyang  WANG Haipeng  ZHU Zhaohui  PANG Zili
Affiliation:1Department of Urology, Uion Hospital, Tongji Medical College, Huazhong University of Sci- ence and Technology, Wuhan, 430022, China)
Abstract:
Objective:To analyze the relationship between overactive bladder(OAB) and bladder outlet obstruc- tion(BOO) in patients with benign prostatic hyperplasia(BPH). Method:Total of 163 patients with BPH were di- vided into 4 severity degrees according to overactive bladder symptom score(OABSS), such as Grade 0(no urgent urination) ; Grade 1(OABSS≤5) ; Grade 2(6-11); Grade 3(OABSS≥12). Prostate three diameters and the intra- vesical prostatic protrusion(IPP) was measured by transabdominal ultrasound. Urodynamic examination included maximum flow rate (Q_max) , P_det @ Q_max, residual urine volume (RUV) and AG value. For statistical analysis AVOVA(analysis of variance) and Spearman correlation were used. Result: In the 163 cases, the OABSS degrees were as follows : Grade 0,44 cases; Grade 1,35 cases ; Grade 2,46 cases and Grade 3,38 cases. There were no sta- tistical significances in age,prostatic volume and Q As the degree of OABSS increased, IPSS increased (Grade 0 to 3: 8.4±4.2, 12.7±3.8, 15.6±3.6, 18.5±4. 1, respectively; F=49.931, P=0.000); IPP increased (Grade 0 to 3: 0.4±0.3, 0.8±0.5, 1. 1±0.7, 1.3±0.6 cm, respectively; F=21. 385, P=0. 000) ; RUV in- creased (Grade 0 to 3: 50.6±36. 1, 64.5±29.0, 68. 3±30.8, 72.7±5.39.2 ml, respectively; F=3. 345, P=0. 021); P_det@Q_max increased (Grade 0 to 3: 48.3±37.5, 53.6±27.9, 58.7±29.1, 70.4±26.8 cmH20, respectively; F=3. 722 ,P=0. 012). It was also found that the OAB symptom was significantly correlated with AG value, bladder outlet obstruction (AG〉40) incidence increased (Grade 0 to 3: 36.4%, 54.3%, 58.7%, 73.7% r= 0. 263, P=0. 001). Conclusion: There is a significant correlation between the OAB symptom and BOO in pa- tients with BPH.
Keywords:benign prostatic hyperplasia  overactive bladder  bladder outlet obstruction
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