| 三氯苯达唑、吡喹酮治疗大鼠斯氏狸殖吸虫病的疗效观察 |
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| 引用本文： | 严亚军,王文林,雷霖. 三氯苯达唑、吡喹酮治疗大鼠斯氏狸殖吸虫病的疗效观察[J]. 中国病原生物学杂志, 2010, 0(4) |
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| 作者姓名： | 严亚军 王文林 雷霖 |
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| 作者单位： | 武汉大学中南医院感染科;昆明医学院寄生虫学教研室; |
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| 摘 要： | 目的观察三氯苯达唑、吡喹酮治疗大鼠斯氏狸殖吸虫病的疗效。方法将30只SD大鼠随机分成6组:三氯苯达唑治疗A组与B组、吡喹酮治疗A组与B组、对照A组与B组,每组5只大鼠。将斯氏狸殖吸虫囊蚴经腹腔注射感染6组大鼠,每只大鼠注射15个囊蚴。治疗A、B组分别于感染后30d和60d用相应药物治疗,用药后第3d剖杀大鼠,回收虫体,计数虫体回收数和虫囊数,计算检虫率及减虫率,并与对照组比较。结果三氯苯达唑治疗A组和吡喹酮治疗A组童虫检虫率分别为(20.00±4.72)%和(21.33±5.58)%,与对照A组(40.00±6.67)%比较,差异均有统计学意义(P0.05);三氯苯达唑治疗A组和吡喹酮治疗A组童虫减虫率分别为50.00%和46.67%,差异无统计学意义(P0.05);三氯苯达唑治疗B组和吡喹酮治疗B组成虫检虫率分别为(2.69±5.95)%和(22.60±8.95)%,与对照B组(53.33±9.43)%比较,差异均有统计学意义(P0.05);三氯苯达唑治疗B组和吡喹酮治疗B组成虫减虫率分别为87.50%和57.50%,差异有统计学意义(P0.05)。结论相同剂量与疗程的三氯苯达唑和吡喹酮治疗斯氏狸殖吸虫感染均有效,其中两药物杀灭斯氏狸殖吸虫童虫效果相似,杀灭成虫效果三氯苯达唑优于吡喹酮。
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| 关 键 词： | 三氯苯达唑 吡喹酮 斯氏狸殖吸虫 大鼠 |
Observation of the therapeutic efficacy of triclabendazole and praziquantel in treating rats with Pagumogonimus skrjabini |
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| YAN Ya-jun,WANG Wen-lin,LEI Lin. Observation of the therapeutic efficacy of triclabendazole and praziquantel in treating rats with Pagumogonimus skrjabini[J]. Journal of Pathogen Biology, 2010, 0(4) |
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| Authors: | YAN Ya-jun WANG Wen-lin LEI Lin |
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| Affiliation: | YAN Ya-jun1,WANG Wen-lin2,LEI Lin2(1.Department of Infectious Disease,Zhongnan Hospital,Wuhan University,Wuhan 430071,China,2.Department of Parasitology,Kunming Medical College,Kunming 650031,China) |
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| Abstract: | Objective To observe the therapeutic effects of triclabendazole and praziquantel in treating rats infected with Pagumogonimus skrjabini.Methods Thirty rats were randomly divided into six groups:triclabendazole treatment groups A and B,praziquantel treatment groups A and B,and control groups A and B.There were 5 rats in each group.The 30 rats were each injected through the abdominal cavity with 15 metacercariae of P.skrjabini.Rats in treatment groups A and B were respectively treated on the 30th day and 60th... |
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| Keywords: | Triclabendazole praziquantel Paragonimus skrjabini rat |
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