肺炎支原体肺炎患儿心肌损伤标志物的变化及结果分析

目的观察肺炎支原体肺炎(MPP)患儿心肌酶谱、肌红蛋白(Mb)、肌钙蛋白I(cTnI)、糖原磷酸化酶同工酶BB(GPBB)的变化,以探讨其在肺炎支原体肺炎诊治中的意义。方法对56例支原体肺炎急性期患儿和50例正常对照组儿童,采用全自动生化分析仪检测血清心肌酶谱变化,选用电化学发光方法检测血清Mb和cTnI含量,采用ELISA方法检测血清GPBB的变化。结果MPP患儿组血清AST、LDH、α-HBDH、CK与正常对照组比较,增高极为显著(p<0.01),CK-MB增高显著(p<0.05);MPP患儿组血清Mb含量比正常对照组显著增高,二者相差极为显著(p<0.01),而cTnI、GPBB与正常对照组比较,增高没有Mb程度大(p<0.05)。结论观察MPP急性期患儿心肌损伤标志物的变化情况对于疾病的诊治非常重要,而且对于研究MPP的发病机理也有帮助。

Developmental changes and results analyse of markers for serum myocardial damage in children with mycoplasma pneumoniae pneumonia

Objective To observe the changes of serum myocardial zymogram, myoglobin(Mb), cardiac troponin I(cTnI), and glycogen phosphorylase isoenzyme BB(GPBB) in children with mycoplasma pneumoniae pneumonia(MPP) and its significance. Methods 56 cases with mycoplasma pneumoniae(Mp) infection in actue stage and 50 healthy children were in this study.The levels of serum myocardial zymogram were measured by aotoanalyer,the concentrations of Mb and cTnI were detected with electrochemiluminescence actual immunity analysator, and level of GPBB was determined by ELISA.Results The levels of serum AST, LDH, α-HBDH,CK and Mb in MPP patients were much higher than that in healthy controls(p<0.01), and the levels of CK-MB, cTnI and GPBB were higher than that in healthy controls(p<0.05).Conclusion It is very important for diagnosis and therapy children with MPP to observe the changes of markers serum myocardial damage.