PAI-1与不同年龄阶段2型糖尿病患者大血管病变关系的研究

目的探讨不同年龄阶段，2型糖尿病患者血浆纤溶酶原激活物抑制物1（PAI-1）与糖尿病大血管病变的关系。方法246例2型糖尿病患者，按年龄及有无大血管并发症分为6组，采用酶联免疫吸附法测定其PAI．1的水平。选取49例正常对照组。结果糖尿病各年龄组在糖尿病病程无差异的情况下，随年龄增长PAI-1水平逐渐升高（P〈0.01）；各相应年龄组中有大血管病变组比无大血管病变组PAI-1水平升高（中青年组P〈0．05，老年组P〈0．01）；多元相关回归分析显示糖尿病有大血管病变组PAI-1与年龄、游离脂肪酸（FFA）、体重指数（BMI）和空腹胰岛素（FINS）相关；仅在青中年组与PAI-1表现相关性的指标是腰臀比（WHR）、甘油三酯（TG）、糖化血清蛋白（GSP）、血尿酸（UA）和FINS。仅在老年组表现相关性的指标是TCH。结论PAI-1水平升高与糖尿病大血管病变有关。PAI-1与年龄显著相关，可能使老年人糖尿病大血管病变发生的机会增加。

The relationship between the levels of plasminogen activator inhibitor-1 and the type 2 diabetes mellitus macrovascular complication in patients with different ages

Objective To investigate the interrelationship between the plasma level of plasminogen activator inhibitor-1(PAI-1) and the type 2 diabetes mellitus macrovascular complication in patients with different ages.Methods The plasma concentrations of PAI-1 were determined by ELISA in 49 control subjects(Control group) and 246 diabetic patients,which were further subdivided into 6 subgroups,based on age and with or without macrovascular complication.Results The PAI-1 levels increased in type 2 diabetes mellitus with increasing age,nevertheless their course of disease were not different(P<0.05);The PAI-1 levels of macrovascular patients were higher than patients without macrovascular in the corresponding age group(the youth and the middle-age group P<0.05,the aged group P<0.01);Multivariant stepwise regression analysis revealed that there was linear regression relationship between PAI-1 and AGE,FFA,BMI and FINS in the diabetes mellitus with macrovascular complication;There were significant positive correlations between PAI-1 and WHR,TG,GSP,FINS and UA in the youth and middle-age group.There were same relationship between PAI-1 and TCH in the aged group.Conclusion The plasma levels of PAI-1 might be correlated to the type 2 diabetes mellitus macrovascular complication.PAI-1 increased along with the increase of age in the diabetic patients.With the increase of PAI-1,the risk of cardiovascular and cerebral vascular diseases would significantly increase in the aged patients.