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No adverse effect of vincristine on handwriting in children after completion of therapy
Authors:Hartman A  van den Bos C  van Dartel N  Stijnen Th  Pieters R
Affiliation:Department of Pediatric Oncology/Hematology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands. j.hartman@erasmusmc.nl
Abstract:
BACKGROUND: Long-term writing difficulties in children after treatment with vincristine for acute lymphoblastic leukemia, Wilms tumor, B non-Hodgkin lymphoma, and malignant mesenchymal tumors, were investigated. PROCEDURE: Handwriting of 33 survivors and 33 controls matched for age, sex, and grade, was assessed with the BHK-scale. The examiner was blinded for whether a child was a case or a control. RESULTS: No significant difference in writing speed was found. Mean difference in number of letters produced during 5 min was 6.4 (+/-67.1, range -103 to +169). No significant difference was found in quality of writing scores; mean difference in points was 1.5 (+/-7.7, range -19 to +22). Cumulative vincristine dose, age at diagnosis or time since completion of treatment did not affect writing speed or quality. CONCLUSION: Chemotherapy, including vincristine, does not lead to long-term problems in speed or quality of writing in children treated for cancer.
Keywords:children  handwriting  vincristine
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