Pharmaco-MEG evidence for attention related hyper-connectivity between auditory and prefrontal cortices in ADHD |
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| Affiliation: | 1. Venom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia, Queensland 4072, Australia;2. Institute for Molecular Bioscience, University of Queensland, St. Lucia, Queensland 4072, Australia;3. HEJ Research Institute of Chemistry, International Centre for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi 75270, Pakistan;4. Australian Venom Research Unit, Department of Pharmacology and Therapeutics, University of Melbourne, Victoria 3010, Australia;5. Monash Venom Group, Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia;6. Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK;7. Molecular Ecology and Evolution Group, School of Biological Sciences, Bangor University, Bangor LL57 2UW, UK;8. Department of Paediatrics, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria 3000, Australia;9. Murdoch Childrens Research Institute, Parkville, Victoria 3052, Australia;10. School of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, Qld 4072, Australia;11. Venom Supplies, Tanunda, SA, Australia |
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| Abstract: | ![]()
The ability to attend to particular stimuli while ignoring others is crucial in goal-directed activities and has been linked with prefrontal cortical regions, including the dorsolateral prefrontal cortex (DLPFC). Both hyper- and hypo-activation in the DLPFC has been reported in patients with attention-deficit/hyperactivity disorder (ADHD) during many different cognitive tasks, but the network-level effects of such aberrant activity remain largely unknown. Using magnetoencephalography (MEG), we examined functional connectivity between regions of the DLPFC and the modality-specific auditory cortices during an auditory attention task in medicated and un-medicated adults with ADHD, and those without ADHD. Participants completed an attention task in two separate sessions (medicated/un-medicated), and each session consisted of two blocks (attend and no-attend). All MEG data were coregistered to structural MRI, corrected for head motion, and projected into source space. Subsequently, we computed the phase coherence (i.e., functional connectivity) between DLPFC regions and the auditory cortices. We found that un-medicated adults with ADHD exhibited greater phase coherence in the beta (14–30 Hz) and gamma frequency (30–56 Hz) range in attend and no-attend conditions compared to controls. Stimulant medication attenuated these differences, but did not fully eliminate them. These results suggest that aberrant bottom-up processing may engulf executive resources in ADHD. |
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| Keywords: | Cortex Magnetoencephalography Stimulants DLPFC Beta Gamma |
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