Oesophageal squamous cell carcinoma in high-risk Chinese populations: Possible role for vascular epithelial growth factor A |
| |
| Affiliation: | 1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA;2. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;3. Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;4. Department of Epidemiology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, People’s Republic of China;5. Shanxi Cancer Hospital, Taiyuan, Shanxi, People’s Republic of China;1. Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, 414 East Clark Street, Vermillion, SD 57069, United States;2. Department of Cellular & Integrative Physiology, University of Nebraska College of Medicine, 985850 Nebraska Medical Center, Omaha, NE 68198-5850, United States;1. European Organisation for Research and Treatment of Cancer (EORTC), Brussels, Belgium;2. Department of Medical Oncology, University of Groningen, University Medical Center, Groningen, The Netherlands;3. NCIC Clinical trials group, Queens University, Kingston, Canada;4. Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States;5. NCI Cancer Imaging Program, National Institutes of Health, Bethesda, MA, United States;1. Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China;2. Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;3. Department of Dentistry, Affiliated Hospital, Weifang Medical University, Weifang 261031, China;1. Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China;2. Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China |
| |
| Abstract: | ![]()
BackgroundMechanisms involved in wound healing play some role in carcinogenesis in multiple organs, likely by creating a chronic inflammatory milieu. This study sought to assess the role of genetic markers in selected inflammation-related genes involved in wound healing (interleukin (IL)-1a, IL-1b, IL-1 Receptor type I (IL-1Ra), IL-1 Receptor type II (IL-1Rb), tumour necrosis factor (TNF)-α, tumour necrosis factor receptor superfamily member (TNFRSF)1A, nuclear factor kappa beta (NF-kB)1, NF-kB2, inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, hypoxia induced factor (HIF)-1α, vascular endothelial growth factor (VEGF)A and P-53) in risk to oesophageal squamous cell carcinoma (OSCC).MethodsWe genotyped 125 tag single nucleotide polymorphism (SNP)s in 410 cases and 377 age and sex matched disease-free individuals from Nutritional Intervention Trial (NIT) cohort, and 546 cases and 556 controls individually matched for age, sex and neighbourhood from Shanxi case–control study, both conducted in high-risk areas of north-central China (1985–2007). Cox proportional-hazard models and conditional logistic regression models were used for SNPs analyses for NIT and Shanxi, respectively. Fisher’s inverse test statistics were used to obtain gene-level significance.ResultsMultiple SNPs were significantly associated with OSCC in both studies, however, none retained their significance after a conservative Bonferroni adjustment. Empiric p-values for tag SNPs in VEGFA in NIT were highly concentrated in the lower tail of the distribution, suggesting this gene may be influencing risk. Permutation tests confirmed the significance of this pattern. At the gene level, VEGFA yielded an empiric significance (P = 0.027) in NIT. We also observed some evidence for interaction between environmental factors and some VEGFA tag SNPs.ConclusionOur finding adds further evidence for a potential role for markers in the VEGFA gene in the development and progression of early precancerous lesions of oesophagus. |
| |
| Keywords: | Oesophageal squamous cell carcinoma Inflammation Wound-healing Genetic marker Genetics Inflammation-related events Vascular endothelial growth factor A |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
