Environmental Isolates of Azole-Resistant Aspergillus fumigatus in Germany |
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| Authors: | Oliver Bader Jana Tünnermann Anna Dudakova Marut Tangwattanachuleeporn Michael Weig Uwe Gro? |
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| Affiliation: | aInstitute for Medical Microbiology, University Medical Center Göttingen, Göttingen, Germany;bFaculty of Allied Health Sciences, Burapha University, Chon Buri, Thailand |
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| Abstract: | ![]()
Azole antifungal drug resistance in Aspergillus fumigatus is an emerging problem in several parts of the world. Here we investigated the distribution of such strains in soils from Germany. At a general positivity rate of 12%, most prevalently, we found strains with the TR34/L98H and TR46/Y121F/T289A alleles, dispersed along a corridor across northern Germany. Comparison of the distributions of resistance alleles and genotypes between environment and clinical samples suggests the presence of local clinical clusters. |
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