血脂康对心肌梗死患者颈动脉结构和功能影响的长期研究

目的：探讨长期服用血脂康对心肌梗死患者颈动脉粥样硬化的影响。方法：65例心肌梗死患者随机分为治疗组和对照组，在常规治疗的基础上，治疗组给予血脂康，对照组给予安慰剂，平均治疗(5.58±1.05)年，治疗前后进行颈动脉超声检查，同时测量血脂的变化。结果：与治疗前和对照组比较，治疗后血脂康组颈动脉内-中膜厚度(IMT)、斑块指数及胆固醇和低密度脂蛋白胆固醇水平明显降低(P<0.05)；且治疗后血脂康组阻力指数、僵硬指数明显低于对照组(P<0.05)；收缩期峰值流速、舒张末期流速、最大剪切率、扩张性系数明显高于对照组(P<0.05)。结论：长期服用血脂康可减缓或阻止动脉粥样硬化的进展，对已形成的动脉粥样硬化和斑块具有逆转和消退作用，对大动脉弹性的改变也有一定的保护作用。

Long-term effect of Xuezhikang on carotid atherosclerosis in patients with myocardial infarction

To investigate the long term effect of Xuezhikang(XZK) on carotid atherosclerosis in patients with myocardial infarction. Methods：Sixty five patients with myocardial infarction were given capsule of 0.6?g XZK, twice a day, or placebo in addition to conventional therapy. The mean follow up was 5.58±1.05 years. Their carotids and lipid levels were examined with high frequency ultrasound checked before and after treatment. Results: XZK efficiently decreased the total cholesterol (TC), the low density lipoprotein cholesterol (LDL C), the lowered intima media thickness (IMT) and the index of atherosclerosis plaque (P<0.05). Compared with control group, resistence index and stiffness index were significantly lower, and the peak velocity in systolic stage, the end velocity in diastolic stage, the maximal shear rate and distensibility coefficient were significantly higher in XZK group (P<0.05). Conclusions: Long term treatment of XZK can slow down or prevent the development of carotid atherosclerosis, fade away and reverse the carotid atherosclerosis plaque. What′s more, it can improve the arterial elasticity.