| 维生素A酸前体制剂的初步研究 |
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| 引用本文： | 张守愚,李焕秋,朱敏,尚文,张瑞香. 维生素A酸前体制剂的初步研究[J]. 沈阳医学院学报, 1994, 0(1) |
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| 作者姓名： | 张守愚 李焕秋 朱敏 尚文 张瑞香 |
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| 作者单位： | 沈阳药学院药物研究所 |
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| 摘 要： | 本文研究了维生素Ａ酸前体制剂，以改变维生素Ａ酸的结构和物理化学性质，达到降低制剂毒性的作用，本文合成了维生素Ａ酸的前体制剂（维生素Ａ酸精氨酸复盐），同时对前体制剂进行红外光谱定性和薄层扫描的定性及定量分析．并对比做了ＶＡ酸和ＶＡ酸前体制剂的ＬＤ５０测定，结果证明其毒性有所降低．
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| 关 键 词： | 维生素A酸，精氨酸，前体制剂 |
A PRELIMINARY STUDY ON THE PRODRUG OF VAACID |
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| Zhang Shouyu Li Huanqiu Zhu Min Shang Wen Zhang RuixiangResearch Institute of Materia Medica,Shenyang College of Pharmacy,Shenyang. A PRELIMINARY STUDY ON THE PRODRUG OF VAACID[J]. Journal of Shenyang Medical College, 1994, 0(1) |
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| Authors: | Zhang Shouyu Li Huanqiu Zhu Min Shang Wen Zhang RuixiangResearch Institute of Materia Medica Shenyang College of Pharmacy Shenyang |
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| Affiliation: | Zhang Shouyu Li Huanqiu Zhu Min Shang Wen Zhang RuixiangResearch Institute of Materia Medica,Shenyang College of Pharmacy,Shenyang 110015 |
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| Abstract: | hrough a study of prodrug retinoic acid it is found that changes in structure and physi-cal and chemical changes may result in a decrease of toxicity. Retinoic acid prodrug(retinoic arginines complex)was first prepared.Qualitative and quantitative analyses by IR and TLC scanner were carried out.The LD50 s of retinoic acid was determined and the prodrug was identified.Results show that the toxicity is decreased. |
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| Keywords: | Retinoic acid Arginines Prodrug |
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