survivin和PTEN蛋白在大肠癌中的表达及临床意义

目的探讨生存素(survivin)和磷酸脂酶(PTEN)蛋白表达与大肠癌浸润转移的关系及相关性。方法应用免疫组织化学技术,检测90例大肠癌组织中survivin和PTEN蛋白表达。结果90例大肠癌中survivin和PTEN蛋白阳性表达率分别为65.6%(59/90)和46.7(42/90)。survivin高表达及PTEN低表达与大肠癌Dukes分期、浆膜浸润、淋巴结转移、肝脏转移均呈正相关(P<0.05)。大肠癌中survivin表达与PTEN表达呈负相关(r=-0.50,P<0.05)。结论survivin和PTEN表达与大肠癌浸润转移密切相关。检测survivin和PTEN蛋白表达可作为判断大肠癌预后的客观指标。

Expression of survivin and PTEN Protein in Human Colorectal Carcinoma and its Clinical Implication

Objective To study the relationship between expression of survivin,PTEN and their correlation to invasion and metastasis in colorectal carcinoma.Methods Immunohistochemical staining was used to detect the expression of survivin and PTEN in 90 cases of colorectal carcinoma.Results In 90 cases of colorectal carcinoma,the expression of survivin and PTEN were 65.5%(59/90) and 46.7%(42/90),respectively.The high level expression of survivin and the low level expression of PTEN were positively correlated with the Dukes staging,serosa infiltration,lymph node and liver metastasis of colorectal carcinoma(P<0.05).The expression of survivin was negatively associated with that of PTEN(r=-0.50,P<0.05).Conclusion These data show a correlation between the survivin and PTEN expression and the potential of invasion and metastasis in colorectal carcinoma.survivin and PTEN may be prognostic indicators in colorectal carcinoma.