| 恶性肿瘤病人血浆可溶性细胞间黏附分子-1水平变化及临床意义 |
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| 引用本文： | 徐文华,段建华,刘成玉. 恶性肿瘤病人血浆可溶性细胞间黏附分子-1水平变化及临床意义[J]. 青岛大学医学院学报, 2001, 37(2): 141-142 |
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| 作者姓名： | 徐文华 段建华 刘成玉 |
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| 作者单位： | 青岛大学 |
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| 摘 要： | ①目的 探讨恶性肿瘤病人血浆可溶性细胞间黏附分子 1(sICAM 1)水平的变化及其临床意义。②方法 采用酶联免疫吸附法 (ELISA) ,检测了 6 6例恶性肿瘤病人和 36例健康人血浆sICAM 1水平的变化。③结果 恶性肿瘤病人血浆sICAM 1水平明显增高 ,与对照组比较 ,差异有极显著性 (t=2 0 .5 6 0 ,P <0 .0 0 1) ,有转移者和死亡者血浆sICAM 1水平明显高于无转移者和存活者 (t =12 .72 5 ,2 5 .919,P <0 .0 0 1) ,且手术治疗前sICAM 1水平明显高于手术治疗后 (t=11.179,P <0 .0 0 1)。④结论 血浆sICAM 1水平变化与恶性肿瘤病人病情变化、有无转移和治疗效果有密切关系
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| 关 键 词： | 肿瘤 细胞黏着分子 血浆 |
| 文章编号： | 1001-4047(2001)02-0141-02 |
| 修稿时间： | 2000-10-20 |
THE CHANGE OF PLASMA SOLUBLE INTERCELLULAR ADHESION MOLECULE-1 LEVEL IN PATIENTS WITH MALIGNANT TUMOR AND ITS CLINICAL SIGNIFICANCE |
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| XU Wenhua,DUAN Jianhua,LIU Chengyu. THE CHANGE OF PLASMA SOLUBLE INTERCELLULAR ADHESION MOLECULE-1 LEVEL IN PATIENTS WITH MALIGNANT TUMOR AND ITS CLINICAL SIGNIFICANCE[J]. Acta Academiae Medicinae Qingdao Universitatis, 2001, 37(2): 141-142 |
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| Authors: | XU Wenhua DUAN Jianhua LIU Chengyu |
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| Affiliation: | XU Wenhua,DUAN Jianhua,LIU Chengyu Department of Biochemistry,Qingdao University Medical College,Qingdao 266021 |
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| Abstract: | Objective To explore the changes of plasma soluble intercellular adhesion molecule 1(sICAM 1) level in patients with malignant tumor and its clinical significance. Methods The change of plasma sICAM 1 level was measured by ELISA in 66 patients with malignant tumor and 36 healthy subjects. Results The plasma sICAM 1 level was significantly higher in patients with malignant tumor than that in controls (t=20.560,P<0.001),The sICAM 1 level in patients with metastasis and death was higher than that in patients without metastasis and survivors (t=12.725,25.919,P<0.001).The sICAM 1 level in patients before operation was higher than that in patients after operation(t=11.179,P<0.001). Conclusion The changes of sICAM 1 were closely related to the severity of illness,with or without metastasis,and effects of treatment in patients with malignant tumor |
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| Keywords: | neoplasms cell adhesion molecules plasma |
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