Diagnostic performance of arginase activity in colorectal cancer |
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| Authors: | del Ara Rangel M González-Polo R A Caro A del Amo E Palomo L Hernández E Soler G Fuentes J M |
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| Affiliation: | (1) Departamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad de Extremadura, Cáceres, Spain, ES;(2) Servicio de Cirugía General, Complejo Hospitalario de Cáceres, Cáceres, Spain, ES;(3) Centro de Salud de Coria, Unidad de Investigación de Cáceres, Cáceres, Spain, ES;(4) Departamento de Bioquímica y Biología Molecular, E. U. Enfermería, Universidad de Extremadura, Avda. de la Universidad s/n 10071, Cáceres, Spain, e-mail: jfuentes@unex.es, Tel.: +34-927-257450, Fax: +34-927-257451, ES |
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| Abstract: | ![]()
Arginase activity was measured in serum and biopsy from healthy individuals and colorectal cancer patients. Arginase activity in tumor samples (87±7.7 U/g tissue) was significantly higher than in controls (40.7±3.3 U/g tissue). However, serum arginase activity did not show any significant change in both groups. Finally, the micromethod used to quantify arginase activity in this study is superior to other methods because it has increased sensitivity, requires less sample, and is less time-consuming. Arginase differences are significant, according to the t-test (P<0.05). Received: 14 September 2001 / Accepted: 6 February 2002 |
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| Keywords: | Arginase Colorectal cancer Rapid assay |
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