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Clinical characteristics of chronic cough detected by 24-hour ambulatory esophageal impedance-pH monitoring in children.

??Abstract??Objective To investigate the characteristics of gastroesophageal reflux disease ??GERD?? with chronic cough by 24-hour ambulatory esophageal impedance-pH monitoring in children. Methods From February 2012 to July 2013?? 40 cases of inpatients and outpatients in Nanjing Children′s Hospital Affiliated to Nanjing Medical University?? who were suspected with gastroesophageal reflux cough ??RERC????were recruited??all these cases underwent 24-hour ambulatory esophageal impedance-pH monitoring. Results Among the 40 children with chronic cough?? 23 patients were diagnosed with GERD refering to pH monitoring??34 children were diagnosed with GERD by 24-hour ambulatory esophageal impedance-pH monitoring. Esophageal acid reflux were significantly higher in the upright than supine position ??P??0.05????and the characteristics of GERD with chronic cough was mainly weak acidic reflux and acid reflux in the upright ??P??0.05????the mixed reflux was the highest frequency in the upright ??P??0.05??. There was no difference between in the upright and supine position about the bolus clearance time??proximal reflux in the supine position was the main way in the total reflux ??P??0.05??. The total reflux and SI demonstrated positive correlation??r = 0.818?? P??0.05??. Conclusion Acid reflux?? weak acid reflux and non-acid reflux can be detected by 24-hour ambulatory esophageal impedance-pH monitoring. The 24-hour ambulatory esophageal impedance-pH monitoring can make more accurate diagnosis of GERD in chronic cough children??and it may have a good prospect for clinical application.