| 11-脱氧甘草次酸的制备 |
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| 引用本文： | 谢松梅,崔慧斐,臧恒昌.11-脱氧甘草次酸的制备[J].中国生化药物杂志,2007,28(2):118-119. |
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| 作者姓名： | 谢松梅 崔慧斐 臧恒昌 |
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| 作者单位： | 山东大学,药学院,生化与生物技术药物研究所,山东,济南,250012 |
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| 摘 要： | 目的制备11-脱氧甘草次酸。方法采用改进的克莱门森反应还原甘草次酸的11位羰基。结果制备了11-脱氧甘草次酸,并通过IR、NMR等手段对其结构进行了鉴定。结论改进的克莱门森还原法制备11-脱氧甘草次酸收率较高,对环境友好,而且简便。
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| 关 键 词： | 甘草次酸 脱氧甘草次酸 克莱门森还原 |
| 文章编号： | 1005-1678（2007）02-0118-02 |
| 收稿时间： | 2006-11-20 |
| 修稿时间： | 2006年11月20 |
The preparation of deoxy-glycyrrhetinic acid |
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| XIE Song-mei,CUI Hui-fei,ZANG Heng-chang.The preparation of deoxy-glycyrrhetinic acid[J].Chinese Journal of Biochemical Pharmaceutics,2007,28(2):118-119. |
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| Authors: | XIE Song-mei CUI Hui-fei ZANG Heng-chang |
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| Institution: | Institute of Biochemical and Biological Drug, School of Pharmaceutical Science, Shandong University, Jinan 250012, China |
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| Abstract: | Purpose To prepare 11-deoxy-glycyrrhetinic acid.MethodsReduction of the 11-caxbonyl group of glycyrrhetinic acid was done through modified Clemmensen reaction.Results11-deoxy-glycyrrhetinic acid was prepared and its structure was characterized by IR and NMR.ConclusionModified Clemmensen reduction was successfully used to prepare 11-deoxy-glycyrrhetinic acid with high yield.The preparing procedure was simple and friendly for environment. |
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| Keywords: | glycyrrhetinic acid deoxy-glycyrrhetinic acid Clemmensen reduction |
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