首页 | 本学科首页   官方微博 | 高级检索  
     

获卵数目与体外受精-胚胎移植结局的关系
引用本文:樊桂玲,彭鹏,韩宝生,李宜学,郭剑. 获卵数目与体外受精-胚胎移植结局的关系[J]. 中国妇幼保健, 2011, 26(27): 4232-4234
作者姓名:樊桂玲  彭鹏  韩宝生  李宜学  郭剑
作者单位:河北省唐山市妇幼保健院 063000
摘    要:目的:分析和探讨体外受精-胚胎移植(IVF-ET)周期最合适的获卵数目。方法:对唐山市妇幼保健院生殖遗传科2009年8月~2010年12月实施的237个IVF-ET新鲜周期进行回顾性总结和分析,根据不同获卵数分为4组:A组≤3、B组4~9、C组10~15及D组>16个卵子,分析各组的周期数、年龄、基础FSH、平均促性腺激素(Gn)启动剂量、用量及天数、HCG注射日的E2值、优胚率和取卵周期临床妊娠率。结果:①获卵数随年龄增加呈下降趋势;②FSH值各组差异无统计学意义;③Gn启动剂量随获卵数增加呈下降趋势,A组与C组、A组与D组、B组与C组差异显著(P<0.01),其余各组差异无统计学意义(P>0.05);④Gn用药天数各组差异无统计学意义;⑤各组Gn总剂量随获卵数增加呈下降趋势但差异无统计学意义(P>0.05);⑥注射HCG日的血清E2值随获卵数增加而明显上升,与获卵数呈正相关,各组之间差异有统计学意义(P<0.01);⑦C组的优胚率及妊娠率高于其他组,差异有统计学意义(P<0.01);⑧D组周期取消数最高,且均因卵巢过度刺激综合征(OHSS)。结论:IVF-ET周期中获卵数在10~15个之间既可以降低OHSS发生,又可获得较理想的妊娠结局。

关 键 词:体外受精-胚胎移植  获卵数  妊娠结局

Relationship between the number of retrieved oocytes and the outcome of in vitro fertilization - embryo transfer
FAN Gui-Ling,PENG Peng,HAN Bao-Sheng et al.Tangshan Maternal , Child Health Hospital,Tangshan ,Hebei,China. Relationship between the number of retrieved oocytes and the outcome of in vitro fertilization - embryo transfer[J]. Maternal and Child Health Care of China, 2011, 26(27): 4232-4234
Authors:FAN Gui-Ling  PENG Peng  HAN Bao-Sheng et al.Tangshan Maternal    Child Health Hospital  Tangshan   Hebei  China
Affiliation:FAN Gui-Ling,PENG Peng,HAN Bao-Sheng et al.Tangshan Maternal and Child Health Hospital,Tangshan 063000,Hebei,China
Abstract:Objective:To analyze and explore the optimal number of retrieved oocytes during in vitro fertilization-embryo transfer(IVF-ET) cycle. Methods:237 fresh IVF-ET cycles carried out in the department of reproductive genetics of the hospital from August 2009 to December 2010 were summarized and analyzed retrospectively,then they were divided into four groups according to different numbers of retrieved oocytes: group A(≤3 oocytes),group B(4~9 oocytes),group C(10~15 oocytes) and group D(>16 oocytes).The numbers of cycles,ages,basic follicle stimulating hormone(FSH) levels,average start doses,dosages and days of gonadotropin,estradiol values on the day of human chorionic gonadotropin(HCG) injection,good quality embryo rates and clinical pregnancy rates during retrieval cycle in the four groups were analyzed. Results:The number of retrieved oocytes showed a decreasing trend with age;there was no significant difference in FSH value among different groups;the start dose of gonadotropin showed a decreasing trend with the increase of the number of retrieved oocytes,there was significant difference between group A and group C,group D,as well as between group B and group D(P<0.01),there was no significant difference among the other groups(P>0.05).There was no significant difference in the time of gonadotropin usage among the four groups;in the four groups,the total dose of gonadotropin showed a decreasing trend with the increase of the number of retrieved oocytes,but there was no significant difference(P>0.05).On the day of HCG injection,the serum estradiol value increased significantly with the increase of the number of retrieved oocytes,which was positively correlated with the number of retrieved oocytes,there was significant difference among the four groups(P<0.01).The good quality embryo rate and clinical pregnancy rate in group C were significantly higher than those in the other three groups(P<0.01).The cancellation rate in group D was the highest,and the reason was ovarian hyperstimulation syndrome(OHSS). Conclusion:In IVF-ET cycle,the occurrence of OHSS can be reduced and a good pregnancy outcome can be obtained when the number of retrieved oocytes is between 10~15.
Keywords:In vitro fertilization-embryo transfer  Number of retrieved oocytes  Pregnancy outcome  
本文献已被 CNKI 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号