| 雌激素代谢酶CYP17、CYP1A2基因多态性与子宫肌瘤易感性的关系 |
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| 引用本文： | 王晓莉,曾静,王璟,陈君辉,胡婷,熊万春.雌激素代谢酶CYP17、CYP1A2基因多态性与子宫肌瘤易感性的关系[J].中国妇幼保健,2011,26(27):4201-4203. |
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| 作者姓名： | 王晓莉 曾静 王璟 陈君辉 胡婷 熊万春 |
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| 作者单位： | 四川省成都市第二人民医院 610017 |
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| 基金项目： | 四川省卫生厅科研基金资助项目 |
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| 摘 要： | 目的:探讨参与雌激素合成和代谢的CYP17和CYP1A2基因多态性与成都地区子宫肌瘤发病的关系。方法:应用聚合酶链反应—限制性片段长度多态性(PCR-RFLP)技术,对100例子宫肌瘤患者和100例对照组人群CYP17基因启动子区T-C多态和CYP1A2基因2964位点G-A多态性进行分析。结果:两组均存在CYP17基因T-C多态,但两组基因型TT、TC、CC频率和等位基因T、C频率的比较差异均无统计学意义(P>0.05);两组均存在CYP1A2基因G-A多态,但两组基因型GG、GA、AA频率和等位基因G、A频率的比较差异均无统计学意义(P>0.05)。结论:CYP17基因启动子区T-C多态和CYP1A2基因2964位点G-A多态性与成都地区子宫肌瘤发病风险无相关性。
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| 关 键 词： | 子宫肌瘤 CYP17基因 CYP1A2基因 遗传多态性 |
Relationship between gene polymorphisms of estrogen metabolic enzymes - CYP17 and CYP1A2 and the susceptibility of hysteromyoma |
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| WANG Xiao-Li,ZENG Jing,WANG Jing et al.Relationship between gene polymorphisms of estrogen metabolic enzymes - CYP17 and CYP1A2 and the susceptibility of hysteromyoma[J].Maternal and Child Health Care of China,2011,26(27):4201-4203. |
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| Authors: | WANG Xiao-Li ZENG Jing WANG Jing |
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| Institution: | WANG Xiao-Li,ZENG Jing,WANG Jing et al.The Second People's Hospital of Chengdu,Chengdu 610017,Sichuan,China |
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| Abstract: | Objective:To explore the relationship between gene polymorphisms of CYP17 and CYP1A2 who participate in the synthesis and metabolism of estrogen and the occurrence of hysteromyoma in Chengdu. Methods:PCR-RFLP was used to analyze T-C polymorphism in CYP17 gene promoter region and G-A polymorphism in 2964 locus of CYP1A2 gene in 100 patients with hysteromyoma and 100 cases in control group. Results:T-C polymorphism of CYP17 gene existed in the two groups,but there was no significant difference in the frequenc... |
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| Keywords: | Hysteromyoma CYP17 gene CYP1A2 gene Gene polymorphism |
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