| 血尿酸水平与氧化应激在急性脑梗死发生中的关系探讨 |
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| 引用本文： | 徐玉龙,刘兆阳,丁琪. 血尿酸水平与氧化应激在急性脑梗死发生中的关系探讨[J]. 卒中与神经疾病, 2010, 17(1): 9-11,19 |
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| 作者姓名： | 徐玉龙 刘兆阳 丁琪 |
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| 作者单位： | 安徽医科大学附属省立医院老年病科,合肥,230001 |
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| 摘 要： | 目的通过了解急性脑梗死(cerebral infarction,CI)患者血清尿酸(uric acid,UA)水平、氧化应激损伤程度及其相互联系,探讨血尿酸升高及氧化应激损伤在60岁以上老年人急性脑梗死发生中的作用。方法随机选择60例急性脑梗死患者(≥60岁)作为脑梗死组和30例健康人为对照组,测定外周血清UA、8-异前列腺素F2a(8-iso prostaglandin F2a,8-iso PGF2a)水平和总超氧化物歧化酶(total superoxide dis-mutase,T-SOD)活力。结果脑梗死组血清UA、8-iso PGF2a水平均高于对照组(P0.01),而T-SOD明显低于对照组(P0.01)。血清UA和8-iso PGF2a之间呈正相关(r=0.698,P0.01),UA和T-SOD活力呈负相关(r=-0.712,P0.01)。8-iso PGF2a与T-SOD活力也呈负相关(r=-0.723,P0.01)。脑梗死组高尿酸血症与正常血尿酸者相比,血浆8-iso PGF2a水平明显增高、T-SOD活力明显降低(P0.01)。结论血清UA水平升高可能是CI的一个危险因素,其可能通过促进氧化应激损伤增加,抗氧化能力降低,导致了CI的发生发展。
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| 关 键 词： | 脑梗死 血尿酸 8-异前列腺素F2a 超氧化物歧化酶 |
Relationship between the level of serum uric acid and oxidative stress in the occurrence of acute cerebral infarction |
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| Xu Yulong,Liu Zhaoyang,Ding Qi. Relationship between the level of serum uric acid and oxidative stress in the occurrence of acute cerebral infarction[J]. Stroke and Nervous Diseases, 2010, 17(1): 9-11,19 |
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| Authors: | Xu Yulong Liu Zhaoyang Ding Qi |
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| Affiliation: | Xu Yulong,Liu Zhaoyang,Ding Qi.Department of Cadre,Anhui Provincial Hospital,Hefei 230001 |
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| Abstract: | Objective To elucidate the effects of elevated serum uric acid(UA) level as well as oxidative stress damage on acute cerebral infarction(CI) by exploring the level of serum UA and oxidative stress damage in the more than 60 years old patients with acute cerebral infarction.Methods The levels of serum UA,8-isoprostan prostaglandin F2a(8-iso-PGF2a) and total superoxide dismutase(T-SOD) activity were measured in 60 patients with acute cerebral infarction and 30 cases of healthy people.Results Compared with the... |
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| Keywords: | Cerebral infarction Serum uric acid 8-iso prostaglandin F2a Superoxide dismutase |
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