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葡萄糖输液的化学稳定性及贮存期
引用本文:陆修祜 丁晓燕. 葡萄糖输液的化学稳定性及贮存期[J]. 华西药学杂志, 1989, 4(4): 213-216
作者姓名:陆修祜 丁晓燕
作者单位:南通医学院附属医院(陆修祜),南通市第一人民医院(丁晓燕)
摘    要:
本文用紫外光度法测定葡萄糖分解产物5-HMF量的上升预测输液化学稳定性及贮存期以代替文献报道的旋光法测葡萄糖下降法。实验表明,5-HMF的logc-t密切相关,符合表观一级反应过程。本法比较了恒温加速及恒温存放的K值,也比较了三种产品的K值,从而比较其内在质量。

关 键 词:葡萄糖输液 化学稳定性 贮存期

THE PREDICTION OF CHEMICAL STABILITY AND STORAGE-LIFE OF GLUCOSE INFUSION
Lu Xiuhu The Affiliated Hospital of Nantong Medical college. THE PREDICTION OF CHEMICAL STABILITY AND STORAGE-LIFE OF GLUCOSE INFUSION[J]. West China Journal of Pharmaceutical Sciences, 1989, 4(4): 213-216
Authors:Lu Xiuhu The Affiliated Hospital of Nantong Medical college
Affiliation:Lu Xiuhu The Affiliated Hospital of Nantong Medical college
Abstract:
In order to predictthe stability and storage-life of glucoseinfusion, An UV spectrophotometer me-thod for the determination of incraased 5-HMF in infusion was used to replace rot-atory raethod for the determination ofdecreased glucose in analysing the chemi-cal kinetics. Accelerated tests showedthat the liner relationship between log5-HMF and time corresponded With pseudofirst order kinetic reaction.
Keywords:Glucose infusion  Chemical stability  5-HMF  kineties of 5-HMF
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