首页 | 本学科首页   官方微博 | 高级检索  
     


Prognostic Impact of NPM1 Mutations in Serbian Adult Patients with Acute Myeloid Leukemia
Authors:Milos Kuzmanovic  Natasa Tosic  Natasa Colovic  Teodora Karan-Djurasevic  Vesna Spasovski  Milena Radmilovic  Gordana Nikcevic  Nada Suvajdzic-Vukovic  Dragica Tomin  Ana Vidovic  Marijana Virijevic  Sonja Pavlovic  Milica Colovic
Affiliation:Institute of Molecular Genetics and Genetic Engineering, Belgrade, Serbia.
Abstract:
Based on current findings, the presence of NPM1 mutations in acute myeloid leukemia (AML) patients is associated with an increased probability of complete remission (CR) and better overall survival (OS). We determined the incidence and prognostic relevance of NPM1 mutations, their association with FLT3 and IDH mutations, and other clinical characteristics in Serbian adult AML patients. Samples from 111 adult de novo AML patients, including 73 AML cases with a normal karyotype (NK-AML), were studied. NPM1, FLT3, and IDH mutations were detected by PCR and direct sequencing. NPM1 mutations were detected in 22.5% of patients. The presence of NPM1 mutations predicted a low CR rate and shorter OS. NPM1 mutations showed an association with both FLT3 and IDH mutations. Survival analysis based on NPM1/FLT3 mutational status revealed a lower OS for NPM1(+)/FLT3(-) compared to the NPM1(-)/FLT3(-) group in NK-AML patients. The lack of impact or unfavorable prognostic effect of NPM1 mutations found in this study can be assigned to a small cohort of analyzed AML patients, as can the presence of FLT3 and IDH mutations or other genetic lesions that cooperate with NPM1 mutations influencing prognosis.
Keywords:
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号