定量磁共振T2映射成像在椎间盘退变中的研究进展

椎间盘退变是引起下腰背痛的主要原因之一，影像学的检查是诊断椎间盘退变的重要手段。传统MRI技术虽可显示椎间盘的信号强度和形态学改变，但很难客观量化椎间盘退变的程度。T2 mapping技术能够检测椎间盘内水含量、蛋白多糖含量及胶原纤维排列顺序等多种生化成分，为椎间盘退变早期临床评估提供新的方法。本文从T2 mapping与其他定量磁共振技术对比，及其与椎间盘退变分级、日本骨科学会评分、视觉模拟评分及年龄、性别等联系论述定量磁共振T2映射成像在椎间盘退变中的研究进展。 

Progress of quantitative magnetic resonance T2 mapping imaging in disc degeneration

Intervertebral disc degeneration is one of the main causes of low back pain. Imaging examination is an important means of diagnose intervertebral disc degeneration. Although traditional MRI technique can show the signal intensity and and morphological changes of the intervertebral disc, it is difficult to objectively quantify the degree of disc degeneration. T2 mapping technology can detect various biochemical components such as intervertebral disc water content, proteoglycan content and collagen fiber sequence, providing a new method for early clinical evaluation of intervertebral disc degeneration. This article discusses the research progress of quantitative magnetic resonance T2 mapping in disc degeneration is discussed from the comparison of T2 mapping with other quantitative magnetic resonance technologies, and its relationship with disc degeneration grade, Japanese Orthopaedic Association score, visual analog scale score, age and gender.