多模融合影像评估再障雄激素治疗相关肝占位的临床研究

目的：探究多模融合影像评估再生障碍性贫血(再障)雄激素治疗相关肝占位的临床价值。方法：选取经超声检查提示肝占位的雄激素治疗再障病人49例为观察组，另选取同期接受治疗的其他肝占位病变病人78例为对照组，所有病人均接受螺旋CT和MRI扫描，将CT与MRI双期图像进行融合，分析多模融合影像在再障雄激素治疗相关肝占位中的评估价值。结果：49例观察组病人经血清生物学检查、穿刺检查、术后组织病理学检查或临床及影像随访>6个月，最终证实观察组肝占位45例，病灶68个，对照组肝占位75例，病灶92个。观察组良性病变占比高于对照组(P<0.05),观察组融合图像的病灶检出率高于CT检查，对照组融合图像的病灶检出率高于CT和MRI检查，差异均有统计学意义(P<0.05),但观察组融合图像的病灶检出率与MRI检查差异无统计学意义(P>0.05)。以手术、病理穿刺及随访后的最终结果为“金标准”,螺旋CT检查诊断再障雄激素治疗相关肝占位的灵敏度、特异度和准确率分别为71.43%、87.50%和80.00%;MRI检查诊断的灵敏度、特异度和准确率分别为85.00%、88.00%和86.67...

Clinical study on the evaluation of hepatic space-occupying lesions related to androgen treatment for aplastic anemia by multi-modality image fusion

ObjectiveTo explore the clinical value of multi-modality image fusion in evaluating hepatic space-occupying lesions related to androgen treatment for aplastic anemia (AA).MethodsTotal 49 patients with AA who had undergone androgen treatment and had hepatic space-occupying lesions detected by ultrasound were selected as the observation group.Meanwhile, 78 patients with the other hepatic space-occupying lesions were selected as the control group.All patients were subjected to spiral CT and MRI scanning.CT and MRI dual-phase images were fused, and the value of multi-modality image fusion in evaluating hepatic space-occupying lesions related to androgen treatment for AA was analyzed.ResultsSerum biological examination, puncture, postoperative histopathological examination or more than 6 months of clinical and imaging follow-up found that there were 45 cases with 68 hepatic space-occupying lesions in the observation group and 75 cases with 92 hepatic space-occupying lesions in the control group.The proportion of benign lesions in the observation group was higher than that in the control group (P < 0.05).The proportion of lesions detected by fusion images was higher than that by CT in the observation group (P < 0.05), and the proportion of lesions detected by fusion images was higher than that by CT or MRI in the control group (P < 0.05), but the proportion of lesions detected by fusion images in the observation group was not significantly different from that in MRI examination (P>0.05).Taking surgical results, pathological results or follow-up results as the golden standard, the sensitivity, specificity and accuracy of spiral CT, MRI and fusion images to diagnose hepatic space-occupying lesions related to androgen treatment for AA were (71.43%, 87.50%, 80.00%), (85.00%, 88.00%, 86.67%) and (100.00%, 94.74%, 97.78%), respectively.The diagnostic value of fusion images was higher than that of CT or MRI (P < 0.05).ConclusionsMulti-modality image fusion has good diagnostic value in evaluating the hepatic space-occupying lesions related to androgen therapy in aplastic anemia.It can improve the detection rate of hepatic space-occupying lesions, and its diagnostic efficiency is better than that of CT or MRI.It is worthy of clinical promotion and application.