胃泌素受体作为分子靶向在肿瘤中的表达及应用

胃泌素(Gas)广泛存在于胃肠道和胰腺组织内,在调控生理功能及某些疾病的发病机制中都有重要作用.近来研究表明,Gas能够促进肿瘤尤其是胃癌、大肠癌等消化系肿瘤的发生、发展.Gas的生物作用主要通过CCK受体介导,Gas mRNA在一些CCK受体阳性的小细胞肺癌,乳腺癌,卵巢癌,不同来源的癌干细胞,已经发现有表达,可能作为这些肿瘤自分泌生长调节的指示指标.对于过表达胃泌素受体的肿瘤,可以给予胃泌素多肽及类似物作放射性标记或连接细胞毒药物,体内用闪烁成像法跟踪显像,从而用于肿瘤的诊断和治疗.

Expression of gastrin receptor in tumors and its application as a molecular target for cancer diagnosis and therapy

Gastrin is widely distributed in gastrointestinal tract and pancreatic tissues,and it plays impor- tant roles in the modulation of physiological functions and pathogenic mechanism of some diseases.Recent studies showed that gastrin might promote the pathogenesis and growth of tumors,especially digestive tumors such as gas- tric cancer and colorectal cancer.The biological effect of gastrin is mainly mediated by chole- cystokinin(CCK)receptors.Gastrin mRNA has been found in CCK-receptor positive small-cell lung carcinoma,breast cancer,ovarian cancer and cancer stem cells of various origins and it may serve as the indicator of self-secretive regu- lation.The tumors with over-expressed gastin receptor can be diagnosed and treated by radio- labelling or linking to the cytotoxic agents with gastin peptide and analogs,and scintigraphy was used to visualize the image in vivo.