可切除胃癌术后复发多因素分析

目的我们对比分析可切除胃癌患者的临床病理资料,试图找出胃癌患者术后复发的早期预知因子。方法该研究包括201例在我院行胃癌根治术的患者,94例患者出现术后复发,107例患者随访无复发。分析对比两组病例的术后病理组织学特征、肿瘤浸润深度、淋巴结转移、术前血清CEA、转移淋巴结与切除淋巴结比率(NR)及术前中性粒细胞与淋巴细胞比值(NLR)等指标,探讨其与胃癌术后复发的关系。结果胃癌术后复发与肿瘤浸润深度、淋巴结转移、NR、NLR、术前血清CEA水平、肿瘤的组织学特征有关(P<0.05),与肿瘤的部位无关(P>0.05);多因素Logistic回归分析表明NLR为胃癌术后复发的独立危险因素。结论 NLR为胃癌术后复发的独立预知因素,能够早期预知胃癌术后复发。

Multiple regression analysis of factors related with recurrence in patients with resectable gastric cancer

Objective We attempt to find out the early prognostic factors of recurrence in patients with gastric cancer who received curative resection by means of contrastive analysis of clinicopathological factors. Methods A total of 201 patients with gastric cancer, who underwent curative resection in our hospital were included. A total of 94 patients were found with recurrence, and 107 patients were without recurrence.Various clinicopathological factors including tumor infiltration depth, pathological and histological characteristics, lymph node metastasis, metastasis lymph nodes ratio（NR）, neutrophil to lymphocyte ratio（NLR）, preoperative serum CEA etc were analyzed retrospectively. Results Chis-Square Test showed that the tumor infiltration depth, lymph node metastasis, NR, NLR, preoperative serum-CEA level and pathological and histological characteristics were statistically significant as risk factors for recurrence（P〈0.05）, meanwhile the region of tumor were unrelated with the tumor histological characteristics（P〉0.05）. Multivariate logistic regression analysis revealed that the lymph node metastasis, NR and NLR were independent risk factor among all the clinicopathologic variables. Conclusion The NLR are independent prognostic indicators of recurrence for patients with resectable gastric cancer, it＆#39;s favourable to early forecast the recurrence in patients with gastric cancer who received curative resection.