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The satiety effect of growth hormone-releasing factor in rats |
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| Authors: | Toshihiro Imaki Tamotsu Shibasaki Mari Hotta Akitsugu Masuda Hiroshi Demura Kazuo Shizume Nicholas Ling |
| Affiliation: | 1. Program in Nutritional Metabolism and Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States;2. Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States;3. Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States |
| Abstract: | The effect of growth hormone-releasing factor (GRF) on feeding behavior in rats was examined. Starvation-induced feeding was suppressed by intraventricular administration of 1 nmol and 4 nmol of synthetic human GRF (hGRF). Food intake was not affected when the peptide was administered by intraperitoneal injection. Furthermore, centrally administered hGRF also suppressed feeding in hypophysectomized rats. These results suggest that GRF suppression of food intake is mediated through the central nervous system independent of its effect on pituitary growth hormone secretion. |
| Keywords: | growth hormone-releasing factor (GRF) feeding behavior |
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