| 全固态乌头碱电化学检测器的研制及其在流动注射分析中的应用 |
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| 引用本文： | 刘万忠,左阿玲. 全固态乌头碱电化学检测器的研制及其在流动注射分析中的应用[J]. 药学学报, 1992, 27(4): 294-298 |
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| 作者姓名： | 刘万忠 左阿玲 |
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| 作者单位： | 湖北省药品检验所,武汉430064 |
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| 摘 要： | 报道一种新型结构的全固态乌头碱电化学检测器的研制及其在流动注射分析中的应用。采用流动注射分析法对川乌、草乌及其中成药(小活络丸)中剧毒成分(双酯型生物碱)进行了测试,方法简便快速,结果同光度法接近。本文还提出了电化学法研究乌头碱水解动力学原理。在pH 6.5,温度98℃的条件下测得乌头碱水解成苯甲酰乌头碱的速度常数为1.36×10-2min-1。
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| 关 键 词： | 乌头碱 电化学检测器 流动注射分析 水解动力学 乌头 小活络丸 |
| 收稿时间： | 1991-05-17 |
CONSTRUCTION AND APPLICATION OF ALL-SOLIDSTATE ACONITINE ELECTROCHEMICAL DETECTOR IN FLOW INJECTION ANALYSIS |
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| WZ Liu,AL Zuo. CONSTRUCTION AND APPLICATION OF ALL-SOLIDSTATE ACONITINE ELECTROCHEMICAL DETECTOR IN FLOW INJECTION ANALYSIS[J]. Acta pharmaceutica Sinica, 1992, 27(4): 294-298 |
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| Authors: | WZ Liu AL Zuo |
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| Affiliation: | Hubei Provincial Institute for Drug Control, Wuhan. |
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| Abstract: | A new kind of all-solid-state electrochemical detector for very toxic alkaloids such as aconitine, mesaconitine and hypaconitine has been studied. It exhibits Nernstian response for these alkaloids with a slope of 56 mV/decade over the concentration range of 3 x 10(-5)-1 x 10(-2) mol/L at pH 2-7 under the flow condition. Direct potentiometry for the determination of aconitine in Aconitum kusnezoffii Reichb., Aconitum carmichaeli Debx. and Xiaohuoluo Wan showed average recoveries of 98.5, 98.3 and 96.8% and relative standard deviations of 1.8, 2.4 and 3.5%, respectively. It can be used for the determination of very toxic alkaloids in the above mentioned samples by flow injection analysis. It also can be used for the study of the hydrolytic kinetics of aconitine. |
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| Keywords: | Electrochemical detector Flow injection analysis Hydrolytic kinetics Aconite Xiaohuoluo Wan Aconitine |
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